HAIRY ROOTS EFFICIENT TOOL FOR THE PRODUCTION OF RECOMBINANT PROTEINS

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NIAZI ALI

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Journal Paper

Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 60-60

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Information Journal Paper

Title

HAIRY ROOTS EFFICIENT TOOL FOR THE PRODUCTION OF RECOMBINANT PROTEINS

Author(s)

NIAZI ALI

Keywords

PROTEIN EXPRESSION HOSTS

HAIRY ROOTS

RECOMBINANT PROTEINS

Abstract

A specific protein is rarely easily enriched from natural host cells. Therefore, recombinant protein production is the only practical procedure. Different recombinant proteins have been produced in prokaryotic hosts but many of them accumulate in the form of inactive inclusion bodies. The inability of prokaryotes to produce native versions of eukaryotic proteins is because of unsuitable posttranslational protein processing, including inappropriate protein cleavage and folding, and to the lake of proper mechanisms that add chemical groups to specific amino acids. Consequently, eukaryotic expression systems were devised for fungal, insect, mammalian cells, and plant hairy roots. Although functional recombinant proteins have been achieved using fungal and insect cells, some mammalian proteins are not correctly glycosylated. In the other side, the mammalian host cells have the high costs. All of these cell hosts can become contaminated with the animal pathogens and sometimes are so costly and complex to be optimized. Hence, hairy roots for recombinant protein production are as one of the interesting technologies. They result from the genetic transformation of plant cells after infection by Agrobacterium rhizogenes. They have interesting advantages including fast growth rate on hormone-free medium, highly branched, and phenotypically and genetically stability. Hairy roots can do all the posttranslational protein processing. The foreign proteins expressed are usually secreted in the culture medium and can be harvested from it with the low cost. This model of recombinant protein production is relatively safe because they are non-host for animal pathogens.

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APA: Copy

NIAZI, ALI. (2014). HAIRY ROOTS EFFICIENT TOOL FOR THE PRODUCTION OF RECOMBINANT PROTEINS. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 60-60. SID. https://sid.ir/paper/336133/en

Vancouver: Copy

NIAZI ALI. HAIRY ROOTS EFFICIENT TOOL FOR THE PRODUCTION OF RECOMBINANT PROTEINS. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):60-60. Available from: https://sid.ir/paper/336133/en

IEEE: Copy

ALI NIAZI, “HAIRY ROOTS EFFICIENT TOOL FOR THE PRODUCTION OF RECOMBINANT PROTEINS,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 60–60, 2014, [Online]. Available: https://sid.ir/paper/336133/en

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