PREDICTIVE VALUES FOR PROCALCITONIN IN THE DIAGNOSIS OF NEONATAL SEPSIS

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ABDEL MOHSEN ABDEL HAKEEM; AHMED KAMEL BOTHINA

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Journal: ELECTRONIC PHYSICIAN Year:2015 | Volume:7 | Issue:4 Page(s): 1190-1195

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Title

PREDICTIVE VALUES FOR PROCALCITONIN IN THE DIAGNOSIS OF NEONATAL SEPSIS

Author(s)

ABDEL MOHSEN ABDEL HAKEEM | AHMED KAMEL BOTHINA | Issue Writer Certificate

Keywords

PROCALCITONIN

C-REACTIVE PROTEIN

NEONATAL SEPSIS

Abstract

Background: Early diagnosis of NEONATAL SEPSIS followed by appropriate treatment decreases mortality and morbidity in infants. The aim of this study is to assess the role of PROCALCITONIN (PCT) as a marker in the early diagnosis of NEONATAL SEPSIS.Methods: We present a cross sectional study where 35 neonates with early onset sepsis (admitted to the Neonatal Intensive Care Units at El-Minia Children University Hospital from August 2012 to August 2013) were included in the study. Another 35 healthy neonates with no clinical or biological data of infection were included as a control group. Subjects were subjected to a thorough history taking and routine laboratory investigations. Serum PCT and C-REACTIVE PROTEIN (CRP) levels were determined by enzyme-linked immunosorbent assay (ELISA).Results: Mean levels of PCT and CRP in neonates with sepsis were significantly higher than in the control group (p=0.0001). There was a moderate, but significant, positive correlation between PCT and C-REACTIVE PROTEIN (p=0.001, r=0.55) and an insignificant correlation between PROCALCITONIN and total leukocytic count among the neonates with sepsis (p=0.2, r=0.2). In addition, PROCALCITONIN had high sensitivity, specificity, a high positive predictive value, and a high negative predictive value (80%, 85.7%, 84.8%, and 81.1% respectively). PROCALCITONIN showed higher sensitivity when compared to CRP.Conclusion: PROCALCITONIN is a sensitive, independent, and useful biomarker in comparison to CRP in early diagnosis of NEONATAL SEPSIS.

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APA: Copy

ABDEL MOHSEN, ABDEL HAKEEM, & AHMED KAMEL, BOTHINA. (2015). PREDICTIVE VALUES FOR PROCALCITONIN IN THE DIAGNOSIS OF NEONATAL SEPSIS. ELECTRONIC PHYSICIAN, 7(4), 1190-1195. SID. https://sid.ir/paper/345352/en

Vancouver: Copy

ABDEL MOHSEN ABDEL HAKEEM, AHMED KAMEL BOTHINA. PREDICTIVE VALUES FOR PROCALCITONIN IN THE DIAGNOSIS OF NEONATAL SEPSIS. ELECTRONIC PHYSICIAN[Internet]. 2015;7(4):1190-1195. Available from: https://sid.ir/paper/345352/en

IEEE: Copy

ABDEL HAKEEM ABDEL MOHSEN, and BOTHINA AHMED KAMEL, “PREDICTIVE VALUES FOR PROCALCITONIN IN THE DIAGNOSIS OF NEONATAL SEPSIS,” ELECTRONIC PHYSICIAN, vol. 7, no. 4, pp. 1190–1195, 2015, [Online]. Available: https://sid.ir/paper/345352/en

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