CENTRAL EFFECT OF HISTAMINE ON FORMALIN –INDUCED PAIN IN RABBITS: ROLE OF OPIOID SYSTEM

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TAMADONFARD E.; AZIMPOURAN A.; BEHJAT B.

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Journal: Journal of Veterinary Research Year:2006 | Volume:61 | Issue:1 Page(s): 83-90

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Title

CENTRAL EFFECT OF HISTAMINE ON FORMALIN –INDUCED PAIN IN RABBITS: ROLE OF OPIOID SYSTEM

Author(s)

TAMADONFARD E. | AZIMPOURAN A. | BEHJAT B. | Issue Writer Certificate

Keywords

BRAINQ3

HISTAMINEQ2

MORPHINEQ3

NALOXONEQ3

FORMALIN PAINQ3

RABBITQ2

Abstract

Objective: To investigate the effect of intracerebroventricular injection of HISTAMINE on pain induced by subcutaneous injection of formalin in the left ear of RABBIT and the effect of the amine on MORPHINE analgesia and NALOXONE hyperalgesia.Design: Experimental study.Animals: Sixty-six male New Zealand white RABBITs weighing 2.640.16 Kg.Procedure: Intracerebroventricular injections of the following drug solutions were done: normal saline (control), HISTAMINE (22.5, 45μg and 90μg), MORPHINE and NALOXONE (50μg and 100 μg), HISTAMINE (45μg) before MORPHINE (50μg) and HISTAMINE (90μg) after NALOXONE (100μg). For induction of Pain Subcutaneous injections of normal saline (control) and formalin (100, 5%) were done Responses including the durations of head and ear movements and ear scratching were recorded in the five min intervals for 1h.Statistical analysis: One-way ANOVA, repeated measures ANOVA and Duncan's test. Results: While normal saline produced any significant response, formalin injection induced a short-lasting (10 min) pain response. HISTAMINE at the dose of 22.5μg had no effect on head and ear movements and scratching durations, but at the doses of 45 and 90μg suppressed the pain response.Morphine (50 and 100μg) and NALOXONE (50 and 100μg) induced antinociception and hyperalgesia, respectively, while I.c.v. injection of HISTAMINE (45μg) before MORPHINE (50μg) increased the antinociceptive effect of MORPHINE Moreover, at the dose of (90μg) after NALOXONE (100μg) attenuated the NALOXONE induced hyperalgesia. Clinical implication: Activation of BRAIN HISTAMINE produces antinociception. MORPHINE induces analgesia and NALOXONE produces hyperalgesia. HISTAMINE potentiates the MORPHINE analgesia and attenuates NALOXONE hyperalgesia. The antinociceptive effect of HISTAMINE may be independent of opioid system.

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APA: Copy

TAMADONFARD, E., AZIMPOURAN, A., & BEHJAT, B.. (2006). CENTRAL EFFECT OF HISTAMINE ON FORMALIN –INDUCED PAIN IN RABBITS: ROLE OF OPIOID SYSTEM. JOURNAL OF VETERINARY RESEARCH, 61(1), 83-90. SID. https://sid.ir/paper/34833/en

Vancouver: Copy

TAMADONFARD E., AZIMPOURAN A., BEHJAT B.. CENTRAL EFFECT OF HISTAMINE ON FORMALIN –INDUCED PAIN IN RABBITS: ROLE OF OPIOID SYSTEM. JOURNAL OF VETERINARY RESEARCH[Internet]. 2006;61(1):83-90. Available from: https://sid.ir/paper/34833/en

IEEE: Copy

E. TAMADONFARD, A. AZIMPOURAN, and B. BEHJAT, “CENTRAL EFFECT OF HISTAMINE ON FORMALIN –INDUCED PAIN IN RABBITS: ROLE OF OPIOID SYSTEM,” JOURNAL OF VETERINARY RESEARCH, vol. 61, no. 1, pp. 83–90, 2006, [Online]. Available: https://sid.ir/paper/34833/en

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