EVALUATION OF POLYMER CONCENTRATION EFFECT ON DOXYCYCLINE HYCLATE DRUG RELEASE FROM IN SITUFORMING SYSTEM BASED ON POLY (LACTIDE-CO-GLYCOLIDE)

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FARROKHZAD H.; MOBEDI H.; BARZIN J.; POORKHALIL A.

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Paper Information

Journal: Iranian Journal of Polymer Science and Technology Year:2010 | Volume:22 | Issue:6 (ISSUE NO. 104) Page(s): 495-505

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Information Journal Paper

Title

EVALUATION OF POLYMER CONCENTRATION EFFECT ON DOXYCYCLINE HYCLATE DRUG RELEASE FROM IN SITUFORMING SYSTEM BASED ON POLY (LACTIDE-CO-GLYCOLIDE)

Author(s)

FARROKHZAD H. | MOBEDI H. | BARZIN J. | POORKHALIL A. | Issue Writer Certificate

Keywords

DRUG RELEASEQ2

DOXYCYCLINE HYCLATEQ3

IN SITU FORMINGQ3

POLY (LACTIDE-CO-GLYCOLIED)Q3

POLYMER CONCENTRATIONQ3

Abstract

In this study, DOXYCYCLINE HYCLATE release behavior from IN SITU FORMING drug delivery systems investigated. These systems based on poly (lactide-co-glycolide) 50: 50 dissolved in N-methyl-2-pyrrolidone that were evaluated in different concentrations. These systems are useful for local treatment of periodontal diseases. UV spectroscopy is used to determine drug concentration in release medium. Also, a new method to stabilize drug in release medium was developed. The structure of prepared membranes is explained by scanning electron microscopy (SEM) to evaluate the surficial and cross-sectional structures of polymer matrices. With increasing in POLYMER CONCENTRATION, surface porosity decreased, membrane structure became denser, burst decreased and DRUG RELEASE time increased.

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APA: Copy

FARROKHZAD, H., MOBEDI, H., BARZIN, J., & POORKHALIL, A.. (2010). EVALUATION OF POLYMER CONCENTRATION EFFECT ON DOXYCYCLINE HYCLATE DRUG RELEASE FROM IN SITUFORMING SYSTEM BASED ON POLY (LACTIDE-CO-GLYCOLIDE). IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), 22(6 (ISSUE NO. 104)), 495-505. SID. https://sid.ir/paper/359466/en

Vancouver: Copy

FARROKHZAD H., MOBEDI H., BARZIN J., POORKHALIL A.. EVALUATION OF POLYMER CONCENTRATION EFFECT ON DOXYCYCLINE HYCLATE DRUG RELEASE FROM IN SITUFORMING SYSTEM BASED ON POLY (LACTIDE-CO-GLYCOLIDE). IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN)[Internet]. 2010;22(6 (ISSUE NO. 104)):495-505. Available from: https://sid.ir/paper/359466/en

IEEE: Copy

H. FARROKHZAD, H. MOBEDI, J. BARZIN, and A. POORKHALIL, “EVALUATION OF POLYMER CONCENTRATION EFFECT ON DOXYCYCLINE HYCLATE DRUG RELEASE FROM IN SITUFORMING SYSTEM BASED ON POLY (LACTIDE-CO-GLYCOLIDE),” IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), vol. 22, no. 6 (ISSUE NO. 104), pp. 495–505, 2010, [Online]. Available: https://sid.ir/paper/359466/en

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