PRODUCTION OF AN EXPERIMENTAL BONDING AGENT CONTAINING DOXYCYCLINE AS MATRIX METALLOPROTEINASE INHIBITOR AND ITS RELEASE RATE

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GHAVAM M.; ARAMI S.; RESHAD M.; IMANI M.; ATAIE M.; MIRZAEI M.; YASINI E.; HASANI TABATABAIE M.; PAHLAVAN A.; KERMANSHAH H.

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Journal: Journal of Dental Medicine Year:2010 | Volume:22 | Issue:4 (61) Page(s): 152-158

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Title

PRODUCTION OF AN EXPERIMENTAL BONDING AGENT CONTAINING DOXYCYCLINE AS MATRIX METALLOPROTEINASE INHIBITOR AND ITS RELEASE RATE

Author(s)

Keywords

DENTIN ADHESIVESQ3

DOXYCYCLINEQ3

MMP INHIBITORQ3

RELEASEQ3

Abstract

Background and Aims: In spite of the advances achieved in the field of DENTIN ADHESIVES, the longevity of bond to dentin is still a challenge. According to recent studies, Matrix Metaloproteinase (MMP) inhibitors can increase clinical longevity of bonding and decrease leakage. The aim of this study was to evaluate the amount and pattern of DOXYCYCLINE RELEASE from an experimental dentin adhesive containing this MMP INHIBITOR.Materials and Methods: In this experimental study, specimens containing 0.25 and 0.5 loading percent of DOXYCYCLINE in an experimental monomer were prepared in cylindrical moulds of 12 mm diameter and 2 mm thickness. The adhesive monomer was composed of 12 wt% Bis-GMA, 10 wt% TMPTMA, 28 wt% HEMA and 50 wt% ethanol. Camphorquinone and amine were used as initiators.Results: Addition of 0.25 and 0.5 w% DOXYCYCLINE showed linear RELEASE in both groups. Increasing the loading percent of DOXYCYCLINE caused more RELEASE. The RELEASE continued during the test period.Conclusion: DOXYCYCLINE RELEASE was observed from the experimental adhesive. Further studies in this field will help in preparing adhesive systems with more clinical longevity.

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References

EFFECT OF ADDING MATRIX METALLOPROTEINASE INHIBITORS ON THE DEGREE OF CONVERSION OF MONOMERS TO POLYMER AN EXPERIMENTAL BONDING AGENT

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APA: Copy

GHAVAM, M., ARAMI, S., RESHAD, M., IMANI, M., ATAIE, M., MIRZAEI, M., YASINI, E., HASANI TABATABAIE, M., PAHLAVAN, A., & KERMANSHAH, H.. (2010). PRODUCTION OF AN EXPERIMENTAL BONDING AGENT CONTAINING DOXYCYCLINE AS MATRIX METALLOPROTEINASE INHIBITOR AND ITS RELEASE RATE. JOURNAL OF DENTAL MEDICINE, 22(4 (61)), 152-158. SID. https://sid.ir/paper/25379/en

Vancouver: Copy

GHAVAM M., ARAMI S., RESHAD M., IMANI M., ATAIE M., MIRZAEI M., YASINI E., HASANI TABATABAIE M., PAHLAVAN A., KERMANSHAH H.. PRODUCTION OF AN EXPERIMENTAL BONDING AGENT CONTAINING DOXYCYCLINE AS MATRIX METALLOPROTEINASE INHIBITOR AND ITS RELEASE RATE. JOURNAL OF DENTAL MEDICINE[Internet]. 2010;22(4 (61)):152-158. Available from: https://sid.ir/paper/25379/en

IEEE: Copy

M. GHAVAM, S. ARAMI, M. RESHAD, M. IMANI, M. ATAIE, M. MIRZAEI, E. YASINI, M. HASANI TABATABAIE, A. PAHLAVAN, and H. KERMANSHAH, “PRODUCTION OF AN EXPERIMENTAL BONDING AGENT CONTAINING DOXYCYCLINE AS MATRIX METALLOPROTEINASE INHIBITOR AND ITS RELEASE RATE,” JOURNAL OF DENTAL MEDICINE, vol. 22, no. 4 (61), pp. 152–158, 2010, [Online]. Available: https://sid.ir/paper/25379/en

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