The effects of mancozeb on the integrity of blood-testis barrier and expression of associated genes

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Mohammadi Sardoo M.; NEMATOLLAHI MAHANI S.N.; NABIUNI M.; MANDEGARY A.; ESLAMINEJAD T.; Amir Heidari B.

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Journal: JOURNAL OF CELL & TISSUE Year:2018 | Volume:9 | Issue:1 Page(s): 56-65

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Title

The effects of mancozeb on the integrity of blood-testis barrier and expression of associated genes

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Keywords

Blood-testis barrierQ1

MancozebQ1

Reproductive dysfunctionsQ1

TestisQ2

Abstract

Aim: The current study was designed to understand the destructive effects of Mancozeb on BTB in an in vitro model. Material and Methods: Male mice were gavage-administered MZB (250, 500 mg/kg w. w) for 40 consecutive days. Integrity of BTB was evaluated using Evans blue dye. The relative mRNA expression of BTB-associated genes; including N-cadherin, claudin-11 and zonula occludens-1 was investigated by quantitative real-time reverse transcription– polymerase chain reaction in different groups (qRT-PCR). Results: Concentration of Evans Blue dye in the lumen of seminiferous tubules was increased in Mancozeb-treated animals. The mRNA expression levels of N-cadherin, claudin-11 and zonula occludens-1 genes were decreased significantly in the MZB 500 mg/kg group compared with the control group. Conclusion: According to the obtained data, it could be concluded that Mancozeb increase BTB permeability leading to testicular dysfunction by the alteration of BTB-associated genes.

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APA: Copy

Mohammadi Sardoo, M., NEMATOLLAHI MAHANI, S.N., NABIUNI, M., MANDEGARY, A., ESLAMINEJAD, T., & Amir Heidari, B.. (2018). The effects of mancozeb on the integrity of blood-testis barrier and expression of associated genes. JOURNAL OF CELL & TISSUE, 9(1 ), 56-65. SID. https://sid.ir/paper/361585/en

Vancouver: Copy

Mohammadi Sardoo M., NEMATOLLAHI MAHANI S.N., NABIUNI M., MANDEGARY A., ESLAMINEJAD T., Amir Heidari B.. The effects of mancozeb on the integrity of blood-testis barrier and expression of associated genes. JOURNAL OF CELL & TISSUE[Internet]. 2018;9(1 ):56-65. Available from: https://sid.ir/paper/361585/en

IEEE: Copy

M. Mohammadi Sardoo, S.N. NEMATOLLAHI MAHANI, M. NABIUNI, A. MANDEGARY, T. ESLAMINEJAD, and B. Amir Heidari, “The effects of mancozeb on the integrity of blood-testis barrier and expression of associated genes,” JOURNAL OF CELL & TISSUE, vol. 9, no. 1 , pp. 56–65, 2018, [Online]. Available: https://sid.ir/paper/361585/en

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