Cytotoxic evaluations of metanolic extract fractions from Haplophyllum tuberculatum against RAJI and A549 cancerous cell lines

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Dastranj F.; KARIMI F.; RAHMANI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Plant Research Year:2018 | Volume:31 | Issue:1 Page(s): 82-92

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Title

Cytotoxic evaluations of metanolic extract fractions from Haplophyllum tuberculatum against RAJI and A549 cancerous cell lines

Author(s)

Dastranj F. | KARIMI F. | RAHMANI N. | Issue Writer Certificate

Keywords

Cytotoxic effectQ1

Haplophyllum tuberculatumQ1

Methanolic ExtractQ2

Abstract

Haplophyllum tuberculatum (Forssk. ) A. Juss., is a perennial plant from Rutaceae which is a valuable folk medicinal plant. The leaves, stem and root samples of shadow dried plants gathered from Hormozgan province-IRAN, were extracted with methanol and total phenolics, flavonoids and alkaloids contents were determined by spectrophotometer. Then the Methanolic Extract was fractionated by di-ethyl-ether, chloroform, butanol, and water respectively. The Cytotoxic effects of fractionated extracts were evaluated against RAJI and A549 cancerous cell lines and intact blood lymphocyte cells by MTT assay. Results showed that the most phenolics were accumulated in stems and the most alkaloids and flavonoids contents were observed in the plant leaves. Di-ethyl-ether extract from all three plant organs had moderate Cytotoxic effect (IC50 < 200 μ g/mL) against A549 cell line. Overall Cytotoxic effects against A549 were more than RAJI cell line. None of the extracts had cytotoxicity against intact blood lymphocyte cells. It seems that the plant chemicals while have no Cytotoxic effects on intact cells, have specific effects on different cancerous cell lines. The results suggest that the purified chemicals of the plant may be benefit for pharmaceutical uses. The present study is the first report on evaluation of cytotoxic activities of fractions with different polarities obtained from Methanolic Extract of Iranian H. tuberculatum species against A549 and RAJI cell lines.

Cites

The Effect of Different Concentrations of Smyrnium cordifolium (F: Apiaceae) Extract on Apoptosis and Proliferation of MCF-7

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APA: Copy

Dastranj, F., KARIMI, F., & RAHMANI, N.. (2018). Cytotoxic evaluations of metanolic extract fractions from Haplophyllum tuberculatum against RAJI and A549 cancerous cell lines. JOURNAL OF PLANT RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 31(1 ), 82-92. SID. https://sid.ir/paper/364448/en

Vancouver: Copy

Dastranj F., KARIMI F., RAHMANI N.. Cytotoxic evaluations of metanolic extract fractions from Haplophyllum tuberculatum against RAJI and A549 cancerous cell lines. JOURNAL OF PLANT RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2018;31(1 ):82-92. Available from: https://sid.ir/paper/364448/en

IEEE: Copy

F. Dastranj, F. KARIMI, and N. RAHMANI, “Cytotoxic evaluations of metanolic extract fractions from Haplophyllum tuberculatum against RAJI and A549 cancerous cell lines,” JOURNAL OF PLANT RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 31, no. 1 , pp. 82–92, 2018, [Online]. Available: https://sid.ir/paper/364448/en

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