The Effect of Zolpidem on Oogenesis and LH, FSH of Adult NMRI Mouse Strain

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MOHAMMADIAN S.; HAYATI ROODBARI N.; PARIVAR K.

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Journal: JOURNAL OF CELL & TISSUE Year:2019 | Volume:10 | Issue:2 Page(s): 72-83

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Title

The Effect of Zolpidem on Oogenesis and LH, FSH of Adult NMRI Mouse Strain

Author(s)

MOHAMMADIAN S. | HAYATI ROODBARI N. | PARIVAR K. | Issue Writer Certificate

Keywords

ZolpidemQ1

OogenesisQ2

LH and FSHQ1

Abstract

Aim: The aim of this study was the effect of Zolpidem on Oogenesis and FSH, LH hormones of female adult NMRI mouse. Material and Methods: In this experimental study thirty adult female mice NMRI strain at a mean weight of 30± 26 grams were divided into five groups Zolpidem solution was prepared in distilled water at 5, 10, and 20 (mg/kg of body weight) doses, and 0. 5 cc injections were doneintraperitoneally every day for 14 days The control group received no injection. The sham group received distilled water and treatment groups of 1, 2, and 3 received doses of 5, 10, and 20 mg/kg The treatment groups were sacrificed one day after the last injection The concentrations of the hormones were measured by the ELISA test The ovary tissue was separated and examined as well as Hematoxylin and eosin painting and the results were evaluated via the tukey-test, (One-way ANOVA) by SPSS program. Results: The results showed a significant decrease in the mean serum FSH, LH levels in the experimental groups compared to the sham and control (P<0. 05) Also histological studies of sections showed the mean number of graffian, secondary and corpus luteum reduced and the mean number of primordial, growing, atretic and abnormal follicles increased. In addition, a significant reduction in the diameter of secondary, graffian follicles and corpus luteum and a significant increased in the diameter of primary, atretic follicles were observed in the experimental groups, compared to the sham and control groups. Conclusion: Injection of Zolpidem significantly is effective on, Oogenesis and concentration of LH, FSH hormones.

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APA: Copy

MOHAMMADIAN, S., HAYATI ROODBARI, N., & PARIVAR, K.. (2019). The Effect of Zolpidem on Oogenesis and LH, FSH of Adult NMRI Mouse Strain. JOURNAL OF CELL & TISSUE, 10(2 ), 72-83. SID. https://sid.ir/paper/364457/en

Vancouver: Copy

MOHAMMADIAN S., HAYATI ROODBARI N., PARIVAR K.. The Effect of Zolpidem on Oogenesis and LH, FSH of Adult NMRI Mouse Strain. JOURNAL OF CELL & TISSUE[Internet]. 2019;10(2 ):72-83. Available from: https://sid.ir/paper/364457/en

IEEE: Copy

S. MOHAMMADIAN, N. HAYATI ROODBARI, and K. PARIVAR, “The Effect of Zolpidem on Oogenesis and LH, FSH of Adult NMRI Mouse Strain,” JOURNAL OF CELL & TISSUE, vol. 10, no. 2 , pp. 72–83, 2019, [Online]. Available: https://sid.ir/paper/364457/en

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