Study of the Gene Expression Changes TNF-Α , BCL2, IL-6, and IL-1β In Male Rats with Nephrolithiasis Treated the Aqueous Extract of Cichorium intybus L. Flower

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Zaman Emamiyan M.; TEHRANIPOUR M.; Hassan Vaezi Gh.; NEJAD SHAHROKH ABADI KH.; SHIRAVI A.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2019 | Volume:12 | Issue: Page(s): 47-58

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Title

Study of the Gene Expression Changes TNF-Α , BCL2, IL-6, and IL-1β In Male Rats with Nephrolithiasis Treated the Aqueous Extract of Cichorium intybus L. Flower

Author(s)

Keywords

Chicory Flower (Cichorium intybus L.)Q1

IL-1βQ1

IL-6Q1

BCL2Q1

TNF-αQ1

Abstract

Inroduction & Objective: Cytokines TNF-α , IL-6, and IL-1β cause an inflammatory response or infection, and ultimately increase cell destruction (reduced expression of anti-apoptotic BCL2 protein) in damaged tissue. In this study, we investigated the effect of the aqueous extract of chicory flower on the expression of relevant genes. Material and Methods: Twenty-four male Wistar rats were assigned to four groups of Since the first day of the intervention, the healthy control group, received ethylene glycol group, prevention groups was administered 50 mg/kg and 200 mg/kg of the aqueous extract of intraperitoneal chicory aqueous extract and 1% ethylene glycol (EG) for the induction of calcium crystals formation. The intervention was continued for 30 days. RNA was extracted from kidney tissues and cDNA was synthesized. Finally, using the Real Time polymerase chain reaction (PCR) technique, the expression levels of IL-1β , IL-6, BCL2, and TNF-α were evaluated. Results: Data analysis by one-way analysis of variance, Tukey's test and software SPSS showed that in the prevention groups 1 and 2, there was a significant increase in BCL2 expression and a significant reduction in TNF-α expression (P<0. 001). Also, the expression of IL-1β significantly increased in rats administered 200 mg of chicory extract, while the expression of IL-6 was significantly enhanced in rats given 50 mg of chicory extract (P<0. 001). Conclusion: Chicory flower extract is effective in eliminating the necrotic effects of TNF-α and consequently, reducing apoptosis in renal epithelial cells. However, it does not affect IL-6, particularly the removal of infection caused by IL-1β .

Cites

Evaluation of Anti-Inflammatory Effect of Chicory Extract on Inflammatory Factors of Interleukin 8 and TNFα in Rats with Polycystic Ovary Syndrome

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APA: Copy

Zaman Emamiyan, M., TEHRANIPOUR, M., Hassan Vaezi, Gh., NEJAD SHAHROKH ABADI, KH., & SHIRAVI, A.. (2019). Study of the Gene Expression Changes TNF-Α , BCL2, IL-6, and IL-1β In Male Rats with Nephrolithiasis Treated the Aqueous Extract of Cichorium intybus L. Flower. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 12(), 47-58. SID. https://sid.ir/paper/369239/en

Vancouver: Copy

Zaman Emamiyan M., TEHRANIPOUR M., Hassan Vaezi Gh., NEJAD SHAHROKH ABADI KH., SHIRAVI A.. Study of the Gene Expression Changes TNF-Α , BCL2, IL-6, and IL-1β In Male Rats with Nephrolithiasis Treated the Aqueous Extract of Cichorium intybus L. Flower. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2019;12():47-58. Available from: https://sid.ir/paper/369239/en

IEEE: Copy

M. Zaman Emamiyan, M. TEHRANIPOUR, Gh. Hassan Vaezi, KH. NEJAD SHAHROKH ABADI, and A. SHIRAVI, “Study of the Gene Expression Changes TNF-Α , BCL2, IL-6, and IL-1β In Male Rats with Nephrolithiasis Treated the Aqueous Extract of Cichorium intybus L. Flower,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 12, no. , pp. 47–58, 2019, [Online]. Available: https://sid.ir/paper/369239/en

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