The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction

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Abdi Hadi; Shamsaei Nabi; JAFARI MOHAMMAD

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Journal: JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT Year:2020 | Volume:7 | Issue:14 Page(s): 103-115

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Title

The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction

Author(s)

Abdi Hadi | Shamsaei Nabi | JAFARI MOHAMMAD | Issue Writer Certificate

Keywords

Aerobic trainingQ2

Stromal cell-derived factor-alphaQ1

Apoptotic deathQ1

Experimental myocardial infarctionQ1

Abstract

Background and Aim: The purpose of this study was to investigate the role of Aerobic training in protein expression of Stromal cell-derived factor-alpha (SDF-1/CXCR4) and cardiomyocyte apoptosis following Experimental myocardial infarction in male rats. Materials and Methods: Twenty six male rats (weight 235 ± 5 kg) were divided into healthy (sham), control, Aerobic training and basic groups. To induce myocardial infarction subcutaneous injection of isoprenaline (150 mg/kg) on two consecutive days with an interval of 24 hours was used. Aerobic training group started training program 48 hours after induction of myocardial infarction. Training program include 4 weeks, 5 sessions per week of running on a treadmill (speed: 10-16 m/minute, Duration: 10-50 minutes, Slope: 5 degree). To study the protein expression and apoptosis, immunohistochemistry (IHC) and TUNNEL staining was used respectively. Data were analyzed using one-way ANOVA and Scheffe tests significant level was set as p<0. 05. Results: The results showed that injection of isoprenaline induced apoptosis and increased protein expression of SDF-1/CXCR4 and its receptor in infarcted rat hearts (p<0. 05). The results also showed that there was significant difference (p<0. 001) in the number of apoptotic cells between training and control group, but in terms of SDF-1/CXCR4 protein expression no significant difference was observed between two groups. Conclusion: Overall results showed that Aerobic training after myocardial infarction can reduce the apoptosis of cardiomyocyte, but did not show any significant effect on protein expression of signaling pathways involved in angiogenesis such as SDF-1/CXCR4.

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APA: Copy

Abdi, Hadi, Shamsaei, Nabi, & JAFARI, MOHAMMAD. (2020). The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, 7(14 ), 103-115. SID. https://sid.ir/paper/373843/en

Vancouver: Copy

Abdi Hadi, Shamsaei Nabi, JAFARI MOHAMMAD. The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT[Internet]. 2020;7(14 ):103-115. Available from: https://sid.ir/paper/373843/en

IEEE: Copy

Hadi Abdi, Nabi Shamsaei, and MOHAMMAD JAFARI, “The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction,” JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, vol. 7, no. 14 , pp. 103–115, 2020, [Online]. Available: https://sid.ir/paper/373843/en

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