The Effect of Eight Weeks of High Intensity Interval Training on Ubiquitin-Proteasome System in Fast Twitch Muscle of Post Myocardial Infarction Rats

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ZOLFAGHARI M.; NEMATI GH.; FATTAHI A.

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Paper Information

Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2020 | Volume:11 | Issue:44 Page(s): 89-106

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Title

The Effect of Eight Weeks of High Intensity Interval Training on Ubiquitin-Proteasome System in Fast Twitch Muscle of Post Myocardial Infarction Rats

Author(s)

ZOLFAGHARI M. | NEMATI GH. | FATTAHI A. | Issue Writer Certificate

Keywords

High-Intensity Interval TrainingQ1

Ubiquitin-Proteasome SystemQ1

Myocardial InfarctionQ1

Fast Twitch MuscleQ1

Abstract

Weakness, intolerance of exercise and eventually muscle atrophy are important features of patients with heart failure. Therefore, the purpose of this study was to investigate the effect of 8 weeks of high intensity interval training on Ubiquitin-Proteasome System in Fast Twitch Muscle of post Myocardial Infarction (MI) rats. Methods: Myocardial Infarction was induced by left artery descending ligation for 30 min. 32 male Wistar rats were randomly divided into 4 groups (n = 8): MI control (MI-CTL), high-intensity interval MI (MI-HIIT), high-intensity interval (HIIT) and Sham-operated. Exercise training was undergoing 40 min, 3 sessions per week for 8-weeks (85-90% VO2max). 24 hours after the last training session, the rats were anesthetized and their extensor digitorum longus (EDL) tissue removed. RT-PCR method was used to measure gene expression (NOX2, TNF-a, NF-KB, P38 MAPK, Murf-1) was used. Data analysis were performed using a one-way ANOVA and Tukey follow up tests, considering as significance level (P < 0. 05). Results: 8-week HIIT significantly decreased NOX2, TNF-a in MI-HIIT compared with MI-CTL and Sham (P=0. 03). These reductions were paralleled a significant decrease in activity NF-KB, P38, Murf-1 in MI-HIIT compared with MI-CTL and Sham (P<0. 05). Also, NOX2 change in HIIT group was significantly higher than MI-CTL and Sham (P<0. 05). According to the results of HIIT probably as an effective treatment, it reduces muscle atrophy in fast muscle contraction of heart patients.

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APA: Copy

ZOLFAGHARI, M., NEMATI, GH., & FATTAHI, A.. (2020). The Effect of Eight Weeks of High Intensity Interval Training on Ubiquitin-Proteasome System in Fast Twitch Muscle of Post Myocardial Infarction Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 11(44 ), 89-106. SID. https://sid.ir/paper/378649/en

Vancouver: Copy

ZOLFAGHARI M., NEMATI GH., FATTAHI A.. The Effect of Eight Weeks of High Intensity Interval Training on Ubiquitin-Proteasome System in Fast Twitch Muscle of Post Myocardial Infarction Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2020;11(44 ):89-106. Available from: https://sid.ir/paper/378649/en

IEEE: Copy

M. ZOLFAGHARI, GH. NEMATI, and A. FATTAHI, “The Effect of Eight Weeks of High Intensity Interval Training on Ubiquitin-Proteasome System in Fast Twitch Muscle of Post Myocardial Infarction Rats,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 11, no. 44 , pp. 89–106, 2020, [Online]. Available: https://sid.ir/paper/378649/en

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