Investigating the anticancer effect of Lippiacitriodora leaf alcoholic extract: suppression of A2780 ovarian cancer cell metastasis via restoration of Ecadherin expression

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AZIMI A.S.; SOLEIMANI MEHRANJANI M.; MAHDIYEH M.

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Journal: JOURNAL OF CELL & TISSUE Year:2019 | Volume:10 | Issue:1 Page(s): 54-62

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Title

Investigating the anticancer effect of Lippiacitriodora leaf alcoholic extract: suppression of A2780 ovarian cancer cell metastasis via restoration of Ecadherin expression

Author(s)

AZIMI A.S. | SOLEIMANI MEHRANJANI M. | MAHDIYEH M. | Issue Writer Certificate

Keywords

Bisphenol AQ1

mesenchymal stem cellsQ1

Osteogenic differentiationQ1

ImmunocytochemistryQ1

Abstract

Aim: The aim of this study was to investigate the effect of Bisphenoln A on Osteogenic differentiation in bone marrow mesenchymal stem cells obtained from adult rat. Material and Methods: Rat bone marrow mesenchymal stem cells were extracted using the flashingout method. At the end of the third passage, cells were divided into groups of control and Bisphenol A treated with different doses of 1, 5, 10, 50, 100, 250, 500, 1000, 2000 and 4000 nM for period of 21 days in the osteogenic media containing 10% of fetal bovine serum. Then rate of Bone matrix mineralization, extracellular calcium deposition, expression of osteopontin and osteocalcin proteins was investigated during the procedure of osteogenesis. Data was analyzed using one-way ANOVA and the means difference was considered significant at p<0. 05. Results: A significant reduction in mean bone matrix mineralization, calcium deposition, expression and synthesis of osteopontin and osteocalcin was seen in the group of cells treated with Bisphenol A when compared to control group (p<0. 05) in a dose and time dependent manner. Conclusion: These results showed that Bisphenol A, as an environmental pollutant, cased a significant reduction in Osteogenic differentiation in rat bone marrow mesenchymal stem cells; therefore, Bisphenol A can be considered as a reducing agent in cell differentiation.

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APA: Copy

AZIMI, A.S., SOLEIMANI MEHRANJANI, M., & MAHDIYEH, M.. (2019). Investigating the anticancer effect of Lippiacitriodora leaf alcoholic extract: suppression of A2780 ovarian cancer cell metastasis via restoration of Ecadherin expression. JOURNAL OF CELL & TISSUE, 10(1 ), 54-62. SID. https://sid.ir/paper/394007/en

Vancouver: Copy

AZIMI A.S., SOLEIMANI MEHRANJANI M., MAHDIYEH M.. Investigating the anticancer effect of Lippiacitriodora leaf alcoholic extract: suppression of A2780 ovarian cancer cell metastasis via restoration of Ecadherin expression. JOURNAL OF CELL & TISSUE[Internet]. 2019;10(1 ):54-62. Available from: https://sid.ir/paper/394007/en

IEEE: Copy

A.S. AZIMI, M. SOLEIMANI MEHRANJANI, and M. MAHDIYEH, “Investigating the anticancer effect of Lippiacitriodora leaf alcoholic extract: suppression of A2780 ovarian cancer cell metastasis via restoration of Ecadherin expression,” JOURNAL OF CELL & TISSUE, vol. 10, no. 1 , pp. 54–62, 2019, [Online]. Available: https://sid.ir/paper/394007/en

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