EFFECT ALCOHOLIC EXTERACTOF KELLUSSIA ODORATISSMA AND B12 ON MARKERS OF INFLAMMATION IN RATS INDUCED EXPERIMENTAL AUTO IMMUNE ENCEPHALOMYELITIS

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KARIMI A.; GOROIE M.

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Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:2 (29) Page(s): 43-50

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Title

EFFECT ALCOHOLIC EXTERACTOF KELLUSSIA ODORATISSMA AND B12 ON MARKERS OF INFLAMMATION IN RATS INDUCED EXPERIMENTAL AUTO IMMUNE ENCEPHALOMYELITIS

Author(s)

KARIMI A. | GOROIE M. | Issue Writer Certificate

Keywords

KELLUSSIA ODORATISSMAQ2

EAEQ2

B12Q2

INFLAMMATION AND RATQ2

Abstract

Inroduction & Objective: MS is an autoimmune disease and inflammation in the central nervous system.KELLUSSIA ODORATISSMA as a traditional medicinal plant has been used as anti-inflammation is some area of Iran. Vitamin B12 properties are regulators of the immune system. This study aimed to determine the effect anti-inflammatory of Kellussia and B12 on Lysosomal enzymes and tissue maker enzymes in Rats with experimental autoimmune encephalomyelitis (EAE).Material and Methods: 50female Rats (180-200gr) divided to 5 groups. EAEwas induced in 40 Rats. KELLUSSIA ODORATISSMA (300 mg/kg) and B12 were Intraperitoneal administered for 10 days to EAE animals. The anti-inflammatory activity was assassed by measuring clinical conditions, levels of lysosomal enzymes, tissue marker enzymes. Results were expressed as Mean ± S.D. and statistical analysis was performed using ANOVA, to determine significant differences between groups.Results: Treatment of EAE rats with KELLUSSIA ODORATISSMA extract and B12 led to significant decreased of clinical conditions, levels of lysosomal enzymes and tissue marker enzymes (p<0.05).Conclusion: KELLUSSIA ODORATISSMA extract and B12 can reduce marker of inflammation and have property anti-inflammation.

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APA: Copy

KARIMI, A., & GOROIE, M.. (2015). EFFECT ALCOHOLIC EXTERACTOF KELLUSSIA ODORATISSMA AND B12 ON MARKERS OF INFLAMMATION IN RATS INDUCED EXPERIMENTAL AUTO IMMUNE ENCEPHALOMYELITIS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(2 (29)), 43-50. SID. https://sid.ir/paper/394419/en

Vancouver: Copy

KARIMI A., GOROIE M.. EFFECT ALCOHOLIC EXTERACTOF KELLUSSIA ODORATISSMA AND B12 ON MARKERS OF INFLAMMATION IN RATS INDUCED EXPERIMENTAL AUTO IMMUNE ENCEPHALOMYELITIS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(2 (29)):43-50. Available from: https://sid.ir/paper/394419/en

IEEE: Copy

A. KARIMI, and M. GOROIE, “EFFECT ALCOHOLIC EXTERACTOF KELLUSSIA ODORATISSMA AND B12 ON MARKERS OF INFLAMMATION IN RATS INDUCED EXPERIMENTAL AUTO IMMUNE ENCEPHALOMYELITIS,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 2 (29), pp. 43–50, 2015, [Online]. Available: https://sid.ir/paper/394419/en

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