Antidepressant effects of quercetin and it nanocrystal on schizophrenia animal model with using forced swimming test

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Mohammadnejad bazkiyaei S.; HAJIZADEH MOGHADDAM A.; Valizadegan F.

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Journal: Journal of Animal Research Year:2017 | Volume:30 | Issue:3 Page(s): 0-0

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Title

Antidepressant effects of quercetin and it nanocrystal on schizophrenia animal model with using forced swimming test

Author(s)

Mohammadnejad bazkiyaei S. | HAJIZADEH MOGHADDAM A. | Valizadegan F. | Issue Writer Certificate

Keywords

depressionQ2

schizophreniaQ1

ketamineQ1

quercetin nanocrystalQ1

Abstract

schizophrenia is a neurodegenerative disease that causes the positive symptoms such as hallucinations and negative symptoms such as social withdrawal and depression. depression is an important co-occurring syndrome in schizophrenia. One of the progressions of the disease, the imbalance between free radicals and antioxidant system. Quercetin, as a neutral antioxidant found in many plants, is widely distributed in edible fruits and vegetables. The purpose of this study was evaluated to protective effect of quercetin and quercetin nanocrystal on depression and activity of catalase and superoxide dismutase enzymes in ketamine model of schizophrenia. In this study, 49 male mice were divided into seven groups: control, vehicle, disease group that received 10mg/kg/day ketamine for 10 days and other four groups that received 10 and 25 mg/kg/day of quercetin and quercetin nanocrystal orally after injection of ketamine. depression disorders using with forced swimming test and the activity of catalase and superoxide dismutase were evaluated. This study shows that injection of ketamine increased immobility and decreased catalase and superoxide dismutase activates (P≤ 0. 001). Treatment with quercetin and it nanocrystal increased significantly mobility time and also increase the activities of these enzymes in in an animal model of schizophrenia (P≤ 0. 001). The results of this study showed that consumption of quercetin nanocrystal decreases depressant disorders and oxidative stress induced by ketamine in model of schizophrenia.

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APA: Copy

Mohammadnejad bazkiyaei, S., HAJIZADEH MOGHADDAM, A., & Valizadegan, F.. (2017). Antidepressant effects of quercetin and it nanocrystal on schizophrenia animal model with using forced swimming test. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(3 ), 0-0. SID. https://sid.ir/paper/396103/en

Vancouver: Copy

Mohammadnejad bazkiyaei S., HAJIZADEH MOGHADDAM A., Valizadegan F.. Antidepressant effects of quercetin and it nanocrystal on schizophrenia animal model with using forced swimming test. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(3 ):0-0. Available from: https://sid.ir/paper/396103/en

IEEE: Copy

S. Mohammadnejad bazkiyaei, A. HAJIZADEH MOGHADDAM, and F. Valizadegan, “Antidepressant effects of quercetin and it nanocrystal on schizophrenia animal model with using forced swimming test,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 3 , pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/396103/en

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