THE EFFECT OF QUERCETIN AND ITS NANOCRYSTALIN ON BEHAVIORAL IMPAIRMENT INDUCED BY KETAMINE INJECTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA

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hosseiny Raziye; HAJIZADEH MOGHADDAM AKBAR; Zare Mahboobeh; MERMOHAMMAD REZAEI FERESHTEH

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2016 | Volume:23 | Issue:122 Page(s): 11-20

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Title

THE EFFECT OF QUERCETIN AND ITS NANOCRYSTALIN ON BEHAVIORAL IMPAIRMENT INDUCED BY KETAMINE INJECTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA

Author(s)

hosseiny Raziye | HAJIZADEH MOGHADDAM AKBAR | Zare Mahboobeh | MERMOHAMMAD REZAEI FERESHTEH | Issue Writer Certificate

Keywords

SCHIZOPHRENIAQ3

QUERCETINQ1

QUERCETIN NANOCRYSTALQ1

BEHAVIORAL IMPAIRMENTQ2

OPEN FIELD TESTQ1

Abstract

Background and Objective: SCHIZOPHRENIA is a chronic debilitating psychiatric disorder, that one of its causative factors is hypoactive N-methyl-D-aspartate receptors. QUERCETIN is a flavonoid that has shown several pharmacological activities such as antioxidant properties and is found in vegetables and fruits. This study was performed with the aim of evaluation of the neuroprotective effect of QUERCETIN and its nanocrystal on BEHAVIORAL IMPAIRMENT induced by ketamine injection in an animal model of SCHIZOPHRENIA.Materials and Methods: In this study, 49 male mice were divided into 7 groups: control, vehicle, lesioned group that received 10 mg/kg/day of ketamine, i.p. for 10 days and other 4 groups that received 10 and 25 mg/kg/day of QUERCETIN and QUERCETIN nanocrystal orally after injection of ketamine. The QUERCETIN nanocrystal was prepared by the evaporative precipitation of nanosuspension (EPN) method. Open field behavioral test was used at 5th and 15th day during gavage with QUERCETIN and QUERCETIN nanocrystal.Results: Results of this study indicated that ketamine injection causes significant BEHAVIORAL IMPAIRMENT in comparison with control group and treatment with QUERCETIN and QUERCETIN nanocrystal improves the BEHAVIORAL IMPAIRMENT.Conclusion: QUERCETIN and QUERCETIN nanocrystal treatment may have a protective effect on brain neurons against harmful effects of ketamine on BEHAVIORAL IMPAIRMENT.

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APA: Copy

hosseiny, Raziye, HAJIZADEH MOGHADDAM, AKBAR, Zare, Mahboobeh, & MERMOHAMMAD REZAEI, FERESHTEH. (2016). THE EFFECT OF QUERCETIN AND ITS NANOCRYSTALIN ON BEHAVIORAL IMPAIRMENT INDUCED BY KETAMINE INJECTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA. DANESHVAR MEDICINE, 23(122 ), 11-20. SID. https://sid.ir/paper/31109/en

Vancouver: Copy

hosseiny Raziye, HAJIZADEH MOGHADDAM AKBAR, Zare Mahboobeh, MERMOHAMMAD REZAEI FERESHTEH. THE EFFECT OF QUERCETIN AND ITS NANOCRYSTALIN ON BEHAVIORAL IMPAIRMENT INDUCED BY KETAMINE INJECTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA. DANESHVAR MEDICINE[Internet]. 2016;23(122 ):11-20. Available from: https://sid.ir/paper/31109/en

IEEE: Copy

Raziye hosseiny, AKBAR HAJIZADEH MOGHADDAM, Mahboobeh Zare, and FERESHTEH MERMOHAMMAD REZAEI, “THE EFFECT OF QUERCETIN AND ITS NANOCRYSTALIN ON BEHAVIORAL IMPAIRMENT INDUCED BY KETAMINE INJECTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA,” DANESHVAR MEDICINE, vol. 23, no. 122 , pp. 11–20, 2016, [Online]. Available: https://sid.ir/paper/31109/en

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