Glucose dependent effect of metformin on expression of two microRNAs-related to epithelial to mesenchymal transition in a gastric cancer cell line

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Valaee Sh.; YAGHOOBI M.M.; Jamshidizad A.; SHAMSARA M.

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Journal: Journal of Molecular and Cellular Researches Year:2019 | Volume:32 | Issue:2 Page(s): 225-235

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Title

Glucose dependent effect of metformin on expression of two microRNAs-related to epithelial to mesenchymal transition in a gastric cancer cell line

Author(s)

Valaee Sh. | YAGHOOBI M.M. | Jamshidizad A. | SHAMSARA M. | Issue Writer Certificate

Keywords

gastric cancerQ1

miR-141Q1

miR-200aQ1

metforminQ1

Abstract

gastric cancer is the fourth most common cancer and the second most cancer related death in the world. It causes the highest mortality rates in Asia. gastric cancer is a progressive malignancy, diagnosed in the metastasis stage in 79% of cases. Epithelial to mesenchymal transition (EMT) is a well-known process, in which tumor cells acquired their invasion properties. MircoRNAs (miRs) are small non-coding RNA molecules regulating EMT suppression/activation epigenetically. For instance, the miR-200 family members are important in EMT suppression and their downregulation occurred in gastric cancer tissue in compare with normal tissues. The members of this family, therefore, might be have diagnostic or therapeutic value. This study was aimed to investigate the glucose-related effects of metformin on expression of miR-141 and mir200a in a gastric cancer cell line. For doing this, The AGS cells were treated with minimal effective dose of metformin (10 mM) determined by MTT for 72 hours and afterwards the target miRs levels were measured by real-time PCR. The results showed the upregulation of the both miR-141 and miR-200a depending on glucose level and metformin exposure time. Glucose differently regulated the expression of the both miRs. Since the suppression of miR-200 family members is associated with a reduction in the survival rate of patients, it is hoped that applying metformin with other standard treatments play a step forward in improving the common treatments of gastric cancer.

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APA: Copy

Valaee, Sh., YAGHOOBI, M.M., Jamshidizad, A., & SHAMSARA, M.. (2019). Glucose dependent effect of metformin on expression of two microRNAs-related to epithelial to mesenchymal transition in a gastric cancer cell line. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 32(2 ), 225-235. SID. https://sid.ir/paper/399934/en

Vancouver: Copy

Valaee Sh., YAGHOOBI M.M., Jamshidizad A., SHAMSARA M.. Glucose dependent effect of metformin on expression of two microRNAs-related to epithelial to mesenchymal transition in a gastric cancer cell line. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2019;32(2 ):225-235. Available from: https://sid.ir/paper/399934/en

IEEE: Copy

Sh. Valaee, M.M. YAGHOOBI, A. Jamshidizad, and M. SHAMSARA, “Glucose dependent effect of metformin on expression of two microRNAs-related to epithelial to mesenchymal transition in a gastric cancer cell line,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 32, no. 2 , pp. 225–235, 2019, [Online]. Available: https://sid.ir/paper/399934/en

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