STUDY OF EGFR GENE IN RELATIONSHIP BETWEEN POLYMORPHISM AND MIR-214 BINDING SITE IN LUNG CANCER

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AMINI FATEMEH; MOTOVALLI BASHI MAJID; HEMMATI SIMIN

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Title

STUDY OF EGFR GENE IN RELATIONSHIP BETWEEN POLYMORPHISM AND MIR-214 BINDING SITE IN LUNG CANCER

Author(s)

AMINI FATEMEH | MOTOVALLI BASHI MAJID | HEMMATI SIMIN | Issue Writer Certificate

Keywords

LUNG CANCERQ2

EGFRQ1

POLYMORPHISMQ2

MIR-214Q1

MIR-27Q1

MIR-128Q1

Abstract

Backgrond: LUNG CANCER is the most common cause of cancer-related deaths worldwide and non-small cell LUNG CANCER (NSCLC), especially adenocarcinoma, is the most common type of LUNG CANCER. Most cases of adenocarcinoma will occur due to KRAS mutations or EGFR mutations and amplifications. The POLYMORPHISM rs884225 which is associated with increased EGFR expression is located in the 3'UTR of the EGFR within the MIR-214 binding site, and near the MIR-27 and MIR-128 binding sites. This study aims to investigate the association between rs884225 and LUNG CANCER in Isfahan population.Materials and Methods: This case-control study was conducted on genomic DNA from the blood samples of 111 healthy subjects and 61 patients. After finishing the primer design, the genotypes were determined using the Tetra Primer ARMSPCR technique. The statistical analysis was performed on the Power Marker software, and the SISA website.Findings: The frequency of the alleles C/T at rs884225 was almost similar among the Isfahan population with and without LUNG CANCER, and a significant association between this POLYMORPHISM and LUNG CANCER wasn't observed (CC: OR=2.24, p>0.05). The Odd Ratio (OR) of this POLYMORPHISM in different kinds of LUNG CANCER was also determined in the population that were not statistically significant (CC in NSCLC: OR=4.6, p>0.05).Conclusion: It seems that no rs884225 is associated with LUNG CANCER, and for more precise conclusions, it is recommended to study in larger statistical societies.

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APA: Copy

AMINI, FATEMEH, MOTOVALLI BASHI, MAJID, & HEMMATI, SIMIN. (2018). STUDY OF EGFR GENE IN RELATIONSHIP BETWEEN POLYMORPHISM AND MIR-214 BINDING SITE IN LUNG CANCER. PAJOUHESH DAR PEZESHKI, 41(4 ), 268-274. SID. https://sid.ir/paper/41939/en

Vancouver: Copy

AMINI FATEMEH, MOTOVALLI BASHI MAJID, HEMMATI SIMIN. STUDY OF EGFR GENE IN RELATIONSHIP BETWEEN POLYMORPHISM AND MIR-214 BINDING SITE IN LUNG CANCER. PAJOUHESH DAR PEZESHKI[Internet]. 2018;41(4 ):268-274. Available from: https://sid.ir/paper/41939/en

IEEE: Copy

FATEMEH AMINI, MAJID MOTOVALLI BASHI, and SIMIN HEMMATI, “STUDY OF EGFR GENE IN RELATIONSHIP BETWEEN POLYMORPHISM AND MIR-214 BINDING SITE IN LUNG CANCER,” PAJOUHESH DAR PEZESHKI, vol. 41, no. 4 , pp. 268–274, 2018, [Online]. Available: https://sid.ir/paper/41939/en

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