THE EFFECT OF L-DOPA ON CREATING MORPHINE DEPENDENCY IN MALE MATURE MICE USING CONDITIONED PLACE PREFERENCE (CPP) METHOD

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HOSSEINI S.E.; FIROZIRAD F.; AQABABA H.

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Journal: EXPERIMENTAL ANIMAL BIOLOGY Year:2012 | Volume:1 | Issue:1 Page(s): 0-0

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Title

THE EFFECT OF L-DOPA ON CREATING MORPHINE DEPENDENCY IN MALE MATURE MICE USING CONDITIONED PLACE PREFERENCE (CPP) METHOD

Author(s)

HOSSEINI S.E. | FIROZIRAD F. | AQABABA H. | Issue Writer Certificate

Keywords

MORPHINE DEPENDENCYQ3

L - DOPAQ2

CONDITIONED PLACE PREFERENCE (CPP) METHODQ2

Abstract

Morphine and other opioid drugs through by increasing brain dopaminergic systems are used to induce dependence and craving. This study investigated the effects of L - DOPA as dopamine precursor on creating dependency of morphine. In this study, 56 male mature mice (about 80 days old) with a weight of 30-35 grams were enrolled as the experimental, sham and the control groups. The experimental groups included 5 subgroups treated with either morphine, L - DOPA with dose of minimum (750 mg/kg), L - DOPA with dose of maximum (1500 mg/kg), morphine+ L - DOPA with dose of minimum and morphine+ L - DOPA with dose of maximum. Morphine was used for dependency and L - DOPA was used as dopamine precursor and CCP method was used to estimate dependency. The data were statistically analyzed by ANOVA using SPSS version 18 Results showed no meaningful difference between the control and the witness groups. However, there was a meaningful difference between the control group with morphine, L - DOPA and L - DOPA +morphine groups in preferring a location to receive morphine (P³0.01). And also no meaningful difference between the L - DOPA +morphine group in preferring the location for receiving the drug compared with the group receiving morphine alone. Morphine through stimulating mesolimbic dopaminergic nerve pathways and L - DOPA through increased production of dopamine in the brain is causes increasing CPP.

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APA: Copy

HOSSEINI, S.E., FIROZIRAD, F., & AQABABA, H.. (2012). THE EFFECT OF L-DOPA ON CREATING MORPHINE DEPENDENCY IN MALE MATURE MICE USING CONDITIONED PLACE PREFERENCE (CPP) METHOD. EXPERIMENTAL ANIMAL BIOLOGY, 1(1), 0-0. SID. https://sid.ir/paper/400916/en

Vancouver: Copy

HOSSEINI S.E., FIROZIRAD F., AQABABA H.. THE EFFECT OF L-DOPA ON CREATING MORPHINE DEPENDENCY IN MALE MATURE MICE USING CONDITIONED PLACE PREFERENCE (CPP) METHOD. EXPERIMENTAL ANIMAL BIOLOGY[Internet]. 2012;1(1):0-0. Available from: https://sid.ir/paper/400916/en

IEEE: Copy

S.E. HOSSEINI, F. FIROZIRAD, and H. AQABABA, “THE EFFECT OF L-DOPA ON CREATING MORPHINE DEPENDENCY IN MALE MATURE MICE USING CONDITIONED PLACE PREFERENCE (CPP) METHOD,” EXPERIMENTAL ANIMAL BIOLOGY, vol. 1, no. 1, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/400916/en

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