Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber

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DINARI MOHAMMAD; Bina Fateme; KHAYAMIAN TAGHI

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Journal: JOURNAL OF APPLIED CHEMISTRY Year:2018 | Volume:13 | Issue:48 Page(s): 41-51

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Information Journal Paper

Title

Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber

Author(s)

DINARI MOHAMMAD | Bina Fateme | KHAYAMIAN TAGHI | Issue Writer Certificate

Keywords

CelecoxibQ1

Sustained releaseQ1

NanofiberQ1

poly(lactic acid)Q1

Abstract

In this study, biodegradable/biocompatible Nanofiber electrospun mats of poly(lactic acid) (PLA), with 8% and 16% of Celecoxib (CX), was used for Sustained release formulations of CX. After optimize condition, the best solvent for electrospinning of PLA system was chloroform/methanol 20% v/v. The morphology of the nanofiers, distribution of the drug inside the nanofiers and possible reactions between polymers and CX in nanofiers were studied by scanning electron microscopy, X-ray diffraction and fourier transform infrared spectroscopy technics. In vitro CX release from the Nanofiber mats were evaluated in solution of HCl (pH = 1. 5), citrate buffer (pH = 3) and carbonate buffer (pH = 8) by using UV-Vis spectroscopy technic. Drug release was dependent to polymer type, CX percent and release environment. CX release in Nanofiber mats of PLA with 8% and 16% w/w of CX, was increased, respectively. Korsemeyer-Peppas release exponent (n) indicates that CX release mechanism was non-Fickian diffusion for formulations of PLA Nanofiber mats.

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APA: Copy

DINARI, MOHAMMAD, Bina, Fateme, & KHAYAMIAN, TAGHI. (2018). Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber. JOURNAL OF APPLIED CHEMISTRY, 13(48 ), 41-51. SID. https://sid.ir/paper/404632/en

Vancouver: Copy

DINARI MOHAMMAD, Bina Fateme, KHAYAMIAN TAGHI. Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber. JOURNAL OF APPLIED CHEMISTRY[Internet]. 2018;13(48 ):41-51. Available from: https://sid.ir/paper/404632/en

IEEE: Copy

MOHAMMAD DINARI, Fateme Bina, and TAGHI KHAYAMIAN, “Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber,” JOURNAL OF APPLIED CHEMISTRY, vol. 13, no. 48 , pp. 41–51, 2018, [Online]. Available: https://sid.ir/paper/404632/en

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