Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release

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Behbood Leila; Arkan Elham; Moradipour Pouran

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:42 | Issue:2 Page(s): 135-142

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Title

Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release

Author(s)

Behbood Leila | Arkan Elham | Moradipour Pouran | Issue Writer Certificate

Keywords

NanofibersQ1

Drug Delivery SystemQ1

SwellingQ1

Drug ReleaseQ1

Controlled ReleaseQ1

Abstract

Background: In the present study, a biocompatible Drug Delivery System was prepared by using chitosan-gelatin Nanofibers based on electrospinning method. Methods: The Nanofibers were prepared by electrospinning and cross-linked by glutaraldehyde to stabilize in aqueous medium. The surface morphology and approximate size of Nanofibers were investigated by the scanning electron microscopy and optical microscope. Results: The Nanofibers were characterized and the interaction types of drug-nanofiber matrix were evaluated by using FT-IR spectrum. The Swelling of Nanofibers was about 3. 88% and the stability of Nanofibers about 3 days was estimated. Conclusion: The Drug Release experiment in phosphate buffer (PBS pH=7. 4) showed that quick release occurred in early hours and then release rate was decrease and Controlled Release was continued for three more days. The results showed that the triamcinolone Drug Delivery System was well implemented and could be used as a functional patch in the future.

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References

Indomethacin electrospun nanofibers for colonic drug delivery: in vitro dissolution studies

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APA: Copy

Behbood, Leila, Arkan, Elham, & Moradipour, Pouran. (2020). Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(2 ), 135-142. SID. https://sid.ir/paper/385036/en

Vancouver: Copy

Behbood Leila, Arkan Elham, Moradipour Pouran. Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(2 ):135-142. Available from: https://sid.ir/paper/385036/en

IEEE: Copy

Leila Behbood, Elham Arkan, and Pouran Moradipour, “Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 2 , pp. 135–142, 2020, [Online]. Available: https://sid.ir/paper/385036/en

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