DEVELOPMENT OF 67GA-BLEOMYCIN COMPLEX FOR TUMOR IMAGING

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JALILIAN A.R.; SHIRAZI B.; RAFIEE H.

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2002 | Volume:- | Issue:25 Page(s): 0-0

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Information Journal Paper

Title

DEVELOPMENT OF 67GA-BLEOMYCIN COMPLEX FOR TUMOR IMAGING

Author(s)

JALILIAN A.R. | SHIRAZI B. | RAFIEE H. | Issue Writer Certificate

Keywords

RADIOPHARMACEUTICALQ2

GALLIUM-67 BLEOMYCINQ4

CYCLOTRONQ4

RADIOISOTOPEQ4

Abstract

The preparation and condition for optimization of 67Ga-labeled bleomicin complex (67Ga-BLM) were undertaken for evaluation of its in vitro/in vivo tumor imaging behavior. Bleomycin (BLM) was successively labeled with 67Ga-gallium chloride obtained from an irradiated 68Zn-metal solid target prepared by electrodeposition at 18 MeV. The best results were obtained at the pH=1 in normal saline as the solvent at 100C in 30 min. Radio thin layer chromatography showed an overall radiochemical yield of 90-94% at the optimized conditions with a specific activity of about 1.39 mCi/mmole and radiochemical purity greater than 93% in 15 min. The final complex was checked by other chromatographic methods to ensure the formation of only one species followed by filtration through a 0.22µ filter.

Cites

تهیه رادیوداروی [In111] ایندویوم بلئومایسین

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APA: Copy

JALILIAN, A.R., SHIRAZI, B., & RAFIEE, H.. (2002). DEVELOPMENT OF 67GA-BLEOMYCIN COMPLEX FOR TUMOR IMAGING. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(25), 0-0. SID. https://sid.ir/paper/406406/en

Vancouver: Copy

JALILIAN A.R., SHIRAZI B., RAFIEE H.. DEVELOPMENT OF 67GA-BLEOMYCIN COMPLEX FOR TUMOR IMAGING. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2002;-(25):0-0. Available from: https://sid.ir/paper/406406/en

IEEE: Copy

A.R. JALILIAN, B. SHIRAZI, and H. RAFIEE, “DEVELOPMENT OF 67GA-BLEOMYCIN COMPLEX FOR TUMOR IMAGING,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 25, pp. 0–0, 2002, [Online]. Available: https://sid.ir/paper/406406/en

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