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Information Journal Paper

Title

An Evaluation of Changes in Cas3, Fibronectin and CoL4a1 Protein Contents following Aerobic and Interval Training with Astaxanthin Supplementation in Heart Tissue of Type 2 Diabetic Rats

Pages

  453-471

Abstract

 diabetes, as a chronic metabolic disorder with a high prevalence, highlights the importance of ongoing research and the need for new methods to prevent and treat this epidemic disease. The aim of this study was to evaluate the changes in fibrosis and apoptosis of heart tissue in diabetic rats following two types of aerobic and interval training with astaxanthin supplementation. 35 male rats were randomly divided into 7 groups after induction of diabetes: diabetes control, diabetes sham, diabetes+aerobic training+supplement, diabetes+interval training+supplement, diabetes+interval training, diabetes+aerobic training, diabetes+supplement. Interval training was performed on the treadmill for 8 weeks, 5 sessions per week with an intensity of 80% vo2max and aerobic training was performed on a treadmill with an intensity of 65-75% Vo2max. The protein contents of Cas3, COL4a1 and fibronectin were measured by Western blotting technique. COL4a1 protein content in both training and combined groups and supplement group showed a significant decrease compared with the control group. Also, the protein contents of Cas3 and fibronectin in the combined and aerobic groups significantly reduced compared to the control group, but there was no significant difference in the content of these proteins between the supplement and interval groups compared to the control group. It seems that the synergistic effects of training with different intensities along with astaxanthin supplementation prevent the upward trend of apoptosis and fibrosis in the heart tissue of diabetic rats and its subsequent complications such as diabetic cardiomyopathy.

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    APA: Copy

    EBADI, NASRIN, ZOLFAGHARI, MOHAMMAD REZA, & GHADERI PAKDEL, FIROUZ. (2021). An Evaluation of Changes in Cas3, Fibronectin and CoL4a1 Protein Contents following Aerobic and Interval Training with Astaxanthin Supplementation in Heart Tissue of Type 2 Diabetic Rats. SPORT BIOSCIENCES (HARAKAT), 12(4 ), 453-471. SID. https://sid.ir/paper/410615/en

    Vancouver: Copy

    EBADI NASRIN, ZOLFAGHARI MOHAMMAD REZA, GHADERI PAKDEL FIROUZ. An Evaluation of Changes in Cas3, Fibronectin and CoL4a1 Protein Contents following Aerobic and Interval Training with Astaxanthin Supplementation in Heart Tissue of Type 2 Diabetic Rats. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2021;12(4 ):453-471. Available from: https://sid.ir/paper/410615/en

    IEEE: Copy

    NASRIN EBADI, MOHAMMAD REZA ZOLFAGHARI, and FIROUZ GHADERI PAKDEL, “An Evaluation of Changes in Cas3, Fibronectin and CoL4a1 Protein Contents following Aerobic and Interval Training with Astaxanthin Supplementation in Heart Tissue of Type 2 Diabetic Rats,” SPORT BIOSCIENCES (HARAKAT), vol. 12, no. 4 , pp. 453–471, 2021, [Online]. Available: https://sid.ir/paper/410615/en

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