The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats

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Amiri Setareh; TOFIGHI ASGHAR; SHIRPOOR ALIREZA; TOLOUEI AZAR JAVAD

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Journal: Sport Physiology and Management Investigations Year:2021 | Volume:13 | Issue:1 Page(s): 21-39

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Title

The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats

Author(s)

Amiri Setareh | TOFIGHI ASGHAR | SHIRPOOR ALIREZA | TOLOUEI AZAR JAVAD | Issue Writer Certificate

Keywords

CTRP-12Q1

furinQ1

KLF-3Q1

KLF-15Q1

moderate intensity continuous trainingQ1

Abstract

One of the factors that counteracts with risk factors of metabolic disorder is CTRP-12. Obesity plays an important role in the downregulation of CTRP-12 by positive regulation of furin and KLF-3 factors and negative regulation of KLF-15. Training affects adipocytes signaling. Therefore, the aim of the present study was to investigate the effect of 12 weeks of moderate intensity continuous training (MICT) on the KLF-15 / KLF-3 / furin / CTRP-12 of visceral adipose tissue in male obese rats. 15 male Wistar rats were divided into two groups: high fat diet (n=10) and standard diet (n=5). After 12 weeks, the high fat diet group was again divided into two groups: MICT and HFD. Training program was performed for 12 weeks, 5 sessions per week with intensity of 50-60% of maximum speed. The values of variables were measured by ELISA method. Data were analyzed using ANOVA and Prism 5 software. The results of this study showed that HFD significantly increased the amount of furin and KLF-3 in visceral adipose tissue (P≤ 0. 05). The 12 weeks of MICT significantly decreased the levels of furin, KLF-3 and significantly increased KLF-15 compared with the HFD group (P≤ 0. 05). Changes in CTRP-12 were not significant between groups (F = 1. 032, P = 0. 386). 12 weeks of MICT, apart from changes in CTRP-12, was effective in decreasing the risk of adipose tissue cellular factors (furin and KLF-3) and in increasing the beneficial factors of adipose tissue (KLF-15). Therefore, it is recommended that those exposed to obesity should get longer training sessions for better cellular adaptation.

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APA: Copy

Amiri, Setareh, TOFIGHI, ASGHAR, SHIRPOOR, ALIREZA, & TOLOUEI AZAR, JAVAD. (2021). The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats. SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS, 13(1 ), 21-39. SID. https://sid.ir/paper/411073/en

Vancouver: Copy

Amiri Setareh, TOFIGHI ASGHAR, SHIRPOOR ALIREZA, TOLOUEI AZAR JAVAD. The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats. SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS[Internet]. 2021;13(1 ):21-39. Available from: https://sid.ir/paper/411073/en

IEEE: Copy

Setareh Amiri, ASGHAR TOFIGHI, ALIREZA SHIRPOOR, and JAVAD TOLOUEI AZAR, “The Effect of 12 Weeks of High Fat Diet and Moderate Intensity Training on the KLF-15 / KLF-3 / Furin / CTRP-12 Pathway of Visceral Adipose Tissue in Male Rats,” SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS, vol. 13, no. 1 , pp. 21–39, 2021, [Online]. Available: https://sid.ir/paper/411073/en

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