Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers

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TABATABAEIAN KHALIL; FALLAH SHOJAEI ABDOLLAH; Yuosef Omandani Shima; Soleymani Hesam

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Journal Paper

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Journal: Journal of Applied Research in Chemistry Year:2020 | Volume:14 | Issue:1 Page(s): 5-13

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Title

Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers

Author(s)

TABATABAEIAN KHALIL | FALLAH SHOJAEI ABDOLLAH | Yuosef Omandani Shima | Soleymani Hesam | Issue Writer Certificate

Keywords

MetalQ1

organic frameworkQ1

UiOQ1

66Q1

NH2Q1

HKUSTQ1

1Q1

drug releaseQ1

Abstract

In this study, the synthesis of Metal-organic frameworks UiO-66-NH2 and HKUST-1 were performed using the solvothermal method. Then, Acetaminophen, Amoxicillin, and Ibuprofen were loaded in UiO-66-NH2 and Ergotamine, Acetaminophen were loaded in HKUST-1 as pharmaceutical models. Subsequently, the performances of these two compounds were evaluated as carrier of these four drugs. Also, the crystalline structures of these nanoparticles were characterized by substrate spectroscopy, X-ray diffraction, and. thermogravimetric analysis. Finally, UV-vis spectroscopy was used to measure the release of the drugs. The results showed that ibuprofen, acetaminophen, and amoxicillin were loaded in UiO-66-NH2 at 1. 2, 0. 7 and 0. 5 mg, respectively, and their release rates during two days were 25, 28 and 43 %, respectively. Also, ergotamine and acetaminophen loaded in HKUST-1 were observed to be 1. 07 and 0. 98 mg, respectively, and their release rates were 35 and 43%, respectively.

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APA: Copy

TABATABAEIAN, KHALIL, FALLAH SHOJAEI, ABDOLLAH, Yuosef Omandani, Shima, & Soleymani, Hesam. (2020). Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(1 ), 5-13. SID. https://sid.ir/paper/411736/en

Vancouver: Copy

TABATABAEIAN KHALIL, FALLAH SHOJAEI ABDOLLAH, Yuosef Omandani Shima, Soleymani Hesam. Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2020;14(1 ):5-13. Available from: https://sid.ir/paper/411736/en

IEEE: Copy

KHALIL TABATABAEIAN, ABDOLLAH FALLAH SHOJAEI, Shima Yuosef Omandani, and Hesam Soleymani, “Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 1 , pp. 5–13, 2020, [Online]. Available: https://sid.ir/paper/411736/en

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