BALANCED CHROMOSOMAL TRANSLOCATIONS OF PARENTS IN RELATION TO SPONTANEOUS ABORTIONS

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HASANZADEH NAZARABADI M.; RAOUFIAN R.; ABOUTORABI ROBAB BEYGOM

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Journal Paper

Paper Information

Journal: Journal of Sciences, Islamic Republic of Iran Year:2005 | Volume:16 | Issue:3 Page(s): 203-208

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Information Journal Paper

Title

BALANCED CHROMOSOMAL TRANSLOCATIONS OF PARENTS IN RELATION TO SPONTANEOUS ABORTIONS

Author(s)

HASANZADEH NAZARABADI M. | RAOUFIAN R. | ABOUTORABI ROBAB BEYGOM | Issue Writer Certificate

Keywords

RECURRENT SPONTANEOUS ABORTION (RSA)

KARYOTYPE

BALANCED TRANSLOCATION

Abstract

The most significant complication of pregnancy is recurrent miscarriage. Numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. Cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of G-banding technique only after other possible etiologic factors have been excluded. The purpose of this study was to determine the frequency of BALANCED TRANSLOCATION in 153 couples who were introduced to the medical genetic laboratory by gynecologists. The prevalence of balanced chromosomal translocation was 9.8% among which 3.3% appeared with Robertsonian translocation and the remaining (6.5%) was evident with different type of balanced chromosomal rearrangement. The yield of positive results for balanced chromosomal translocation carrier was lower than that expected. With regard to the low incidence of BALANCED TRANSLOCATION in normal population and high cost and time-consumption of chromosomal analysis cytogenetic investigation should be suggested only in couples with recurrent spontaneous abortions when clinical data fail to clarify the cause

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APA: Copy

HASANZADEH NAZARABADI, M., RAOUFIAN, R., & ABOUTORABI, ROBAB BEYGOM. (2005). BALANCED CHROMOSOMAL TRANSLOCATIONS OF PARENTS IN RELATION TO SPONTANEOUS ABORTIONS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 16(3), 203-208. SID. https://sid.ir/paper/530749/en

Vancouver: Copy

HASANZADEH NAZARABADI M., RAOUFIAN R., ABOUTORABI ROBAB BEYGOM. BALANCED CHROMOSOMAL TRANSLOCATIONS OF PARENTS IN RELATION TO SPONTANEOUS ABORTIONS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2005;16(3):203-208. Available from: https://sid.ir/paper/530749/en

IEEE: Copy

M. HASANZADEH NAZARABADI, R. RAOUFIAN, and ROBAB BEYGOM ABOUTORABI, “BALANCED CHROMOSOMAL TRANSLOCATIONS OF PARENTS IN RELATION TO SPONTANEOUS ABORTIONS,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 16, no. 3, pp. 203–208, 2005, [Online]. Available: https://sid.ir/paper/530749/en

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