ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN

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EDRISIAN GH.H.; AFSHAR A.; SAYADZADEH A.; MOHSSENI G.; SATVAT M.T.

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Journal: JOURNAL OF TROPICAL MEDICINE AND HYGIENE Year:1993 | Volume:96 | Issue:4 Page(s): 237-240

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Title

ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN

Author(s)

Keywords

PLASMODIUM-FALCIPARUM

SULFADOXINE PYRIMETHAMINE

RESISTANCE

IRAN

Abstract

Studies of drug RESISTANCE of Plasmodium falciparum cases from SE IRAN were carried out in vivo and in vitro during 1990-91. In a study of 26 chloroquine-resistant infections, using amodiaquine (25 mg kg-1 over 3 days), followed by two-thirds of the standard dose of sulphadoxine-pyrimethamine, six cases were resistant at the RI(3) and RII(3) levels. An additional study testing the standard dose of sulphadoxine-pyrimethamine in 43 chloroquine-resistant cases revealed five (11.6%) resistant at the RI(2) and RII(3) levels. Six of the above resistant infections were contracted in Hormozgan, three in Sistan-Baluchestan, one in Kerman provinces of IRAN and one in Pakistan.In five of 22 successful in-vitro tests, carried out on different isolates, the parasites grew to schizonts (greater-than-or-equal-to 8 nuclei) in the wells containing 1000 pmol sulphadoxine and 12.5 pmol pyrimethamine, indicative of RESISTANCE.

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APA: Copy

EDRISIAN, GH.H., AFSHAR, A., SAYADZADEH, A., MOHSSENI, G., & SATVAT, M.T.. (1993). ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN . JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 96(4), 237-240. SID. https://sid.ir/paper/531492/en

Vancouver: Copy

EDRISIAN GH.H., AFSHAR A., SAYADZADEH A., MOHSSENI G., SATVAT M.T.. ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN . JOURNAL OF TROPICAL MEDICINE AND HYGIENE[Internet]. 1993;96(4):237-240. Available from: https://sid.ir/paper/531492/en

IEEE: Copy

GH.H. EDRISIAN, A. AFSHAR, A. SAYADZADEH, G. MOHSSENI, and M.T. SATVAT, “ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN ,” JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 96, no. 4, pp. 237–240, 1993, [Online]. Available: https://sid.ir/paper/531492/en

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