مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BENZOCAINE BY DICYCLOHEXYL-18-CROWN-6 AND CALMAGITE

Pages

  121-124

Abstract

 A simple and sensitive extraction-spectrophotometric method for rapid and accurate determination of benzocaine in pure and dosage forms was developed. Benzocaine was effectively extracted as a 1:1 ion pair complex with dicyclohexyl- 18-crown-6 and calmagite in acidic media into chloroform, followed by spectrophotometric determination at 486 nm. Molar absorptivity of the ternary complex at this wavelength was 5.25×103 l mol-1 cm-1. Beer’s law was obeyed over the range 1.65-132 μg/ml of benzocaine and the minimum detectable amount of the drug was 0.6 μg/ml. The method was successfully applied to the determination of benzocaine in a cream sample.

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    • Cite

    APA: Copy

    MADRAKIAN, T., SHAMSIPOUR, M., & AFKHAMI, A.. (2002). EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BENZOCAINE BY DICYCLOHEXYL-18-CROWN-6 AND CALMAGITE. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 13(2), 121-124. SID. https://sid.ir/paper/532073/en

    Vancouver: Copy

    MADRAKIAN T., SHAMSIPOUR M., AFKHAMI A.. EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BENZOCAINE BY DICYCLOHEXYL-18-CROWN-6 AND CALMAGITE. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2002;13(2):121-124. Available from: https://sid.ir/paper/532073/en

    IEEE: Copy

    T. MADRAKIAN, M. SHAMSIPOUR, and A. AFKHAMI, “EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BENZOCAINE BY DICYCLOHEXYL-18-CROWN-6 AND CALMAGITE,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 13, no. 2, pp. 121–124, 2002, [Online]. Available: https://sid.ir/paper/532073/en

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