EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE

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REIHANI-SABET F.; ELAHI E.; KHANIPOUR-ROSHAN M.; MAHMOUDI M.; ESKANDARPOUR M.

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Journal: Journal of Sciences, Islamic Republic of Iran Year:2003 | Volume:14 | Issue:1 Page(s): 11-16

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Title

EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE

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Keywords

HELICOBACTER PYLORI; CD44; ADHESION MOLECULE; INFLAMMATION; STOMACH; CANCER

Abstract

Helicobacter pylori (H. pylori) infection, which is always accompanied by inflammation, and increased expression of the cell adhesion molecule CD44 have both been purported to be correlated with gastric cancer. Specifically, altered expression of alternatively spliced CD44 transcripts has been found in many cancers, including cancer of the stomach. Considering the association between H. pylori infection and inflammation, it is possible that the correlation between CD44 alternative splicing and gastric cancer is due to inflammation. To test this, we compared the expression of all CD44 variant exons V2-V10 in non-cancerous individuals with and without inflammation. To ascertain the extent to which the effect of H. pylori is mediated by inflammation, CD44 variant exon expression in inflamed individuals with and without H. pylori infection was compared.CD44 variant exon expression was assessed in gastric biopsy samples of 43 H. pylori infected (H. pylori+) and 46 non-infected (H. pylori-) individuals using nested RT-PCR. Thirteen of the non-infected individuals were without inflammation. The results suggest that inflammation alone does not change CD44 expression. There was a significant correlation between the expression of CD44 variant exons V8, V9 and V10 and H. pylori infection. Further investigations will be necessary to address the possibility that infection and inflammation have synergistic roles in the increased expression of V8, V9 and V10. These exons code for parts of the extracellular portion of the protein and changes in their expression may affect oncogenic processes because of changed affinities for the extracellular matrix.

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APA: Copy

REIHANI-SABET, F., ELAHI, E., KHANIPOUR-ROSHAN, M., MAHMOUDI, M., & ESKANDARPOUR, M.. (2003). EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 14(1), 11-16. SID. https://sid.ir/paper/542266/en

Vancouver: Copy

REIHANI-SABET F., ELAHI E., KHANIPOUR-ROSHAN M., MAHMOUDI M., ESKANDARPOUR M.. EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2003;14(1):11-16. Available from: https://sid.ir/paper/542266/en

IEEE: Copy

F. REIHANI-SABET, E. ELAHI, M. KHANIPOUR-ROSHAN, M. MAHMOUDI, and M. ESKANDARPOUR, “EFFECTS OF INFLAMMATION AND H. PYLORI INFECTION ON EXPRESSION OF CD44 VARIANT EXONS IN GASTRIC TISSUE,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 14, no. 1, pp. 11–16, 2003, [Online]. Available: https://sid.ir/paper/542266/en

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