THE EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA LEAVES ON LIVER ENZYMATIC ACTIVITIES IN ALLOXAN- INDUCED DIABETIC RATS

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RAHIMI PARIVASH; MADANI HOSSEIN; MAHZOUNI P.

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Journal: RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE" Year:2008 | Volume:35 | Issue:6 Page(s): 103-110

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA LEAVES ON LIVER ENZYMATIC ACTIVITIES IN ALLOXAN- INDUCED DIABETIC RATS

Author(s)

RAHIMI PARIVASH | MADANI HOSSEIN | MAHZOUNI P. | Issue Writer Certificate

Keywords

ALLOXAN MONOHYDRATEQ3

DIABETESQ3

JUGLANS REGIAQ3

HYDROALCOHOLIC EXTRACTQ3

RATQ3

Abstract

Diabetes is a metabolic disorder characterised by hyperglycemia resulting from perturbation in insulin secretion, insulin action or both. JUGLANS REGIA (Juglandaceae) has been used in Iranian ethno - medicine in the treatment of DIABETES. In this experience the preventive effect of HYDROALCOHOLIC EXTRACT of JUGLANS REGIA leaves on activity of AST and ALT in alloxan - induced diabetic RATs was investigated. 18 male Wistar RATs, with body weights of 180–220 g were randomly allocated into three groups with six animals per group: first group, nondiabetic RATs; second group, diabetic RATs; third group, nondiabetic RATs treated with HYDROALCOHOLIC EXTRACT of JUGLANS REGIA leaves (200 mgkg-1B.W.) before and then inducion DIABETES. In order to induce DIABETES, alloxan was administered as a single dose (120 mgkg-1B.W.), intraperitoneally. At the initial and the end of 2 and 6 weeks of experimental period, RATs were fasted for 16h, and then fasting blood samples were collected in heparinated tubes. Sampling was performed from the orbital sinus. The results indicate a significant difference in AST and ALT levels in the diabetic group compared with the other groups (p<0.05). Histological studies of the liver of these animals, demonstrated the same results. These results show that the HYDROALCOHOLIC EXTRACT of JUGLANS REGIA leaves could effect on prevent and improve the symptoms of DIABETES.

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APA: Copy

RAHIMI, PARIVASH, MADANI, HOSSEIN, & MAHZOUNI, P.. (2008). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA LEAVES ON LIVER ENZYMATIC ACTIVITIES IN ALLOXAN- INDUCED DIABETIC RATS. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", 35(6), 103-110. SID. https://sid.ir/paper/55927/en

Vancouver: Copy

RAHIMI PARIVASH, MADANI HOSSEIN, MAHZOUNI P.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA LEAVES ON LIVER ENZYMATIC ACTIVITIES IN ALLOXAN- INDUCED DIABETIC RATS. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE"[Internet]. 2008;35(6):103-110. Available from: https://sid.ir/paper/55927/en

IEEE: Copy

PARIVASH RAHIMI, HOSSEIN MADANI, and P. MAHZOUNI, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA LEAVES ON LIVER ENZYMATIC ACTIVITIES IN ALLOXAN- INDUCED DIABETIC RATS,” RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", vol. 35, no. 6, pp. 103–110, 2008, [Online]. Available: https://sid.ir/paper/55927/en

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