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Cites:

1

Information Journal Paper

Title

DRUG NANO-PARTICLES FORMATION BY SUPERCRITICAL RAPID EXPANSION METHOD; OPERATIONAL CONDITION EFFECTS INVESTIGATION

Pages

  7-15

Abstract

 Dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for RESS (Rapid Expansion of SUPERCRITICAL Solution) process. SUPERCRITICAL CO2 was used as solvent and Ibuprofen was applied as the model component in all runs. The resulting Ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by SEM and laser diffraction particle size analyzer systems.Results show that in low SUPERCRITICAL pressure ranges, depending on the solvent and solid component properties (Lower than 105 bar for Ibuprofen-CO2 system), nozzle temperature should be as low as possible (80-90oC for Ibuprofen-CO2 system).In the other hand in high SUPERCRITICAL pressure ranges (above 105 bar), high nozzle temperatures work better. The border line of these two areas depends on the solvent phase behavior. RAPID EXPANSION of SUPERCRITICAL Solution into a liquid solvent (RESOLV) was also studied with and without the presence of surfactant and compared with RESS process by measuring of formed particles size, SIZE DISTRIBUTION and DISSOLUTION RATE. Results show that the RESS process generally creates better conditions for achieving fine and uniform organic powders (with mean particles size of 40-180 nm), in contrast to the RESOLV method (minimum particles size of 80-400 nm).

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    APA: Copy

    ZABIHI, FATEMEH, AKBARNEJAD, MOHAMMAD MAHDI, VAZIRI YAZDI, ALI, ARJOMAND, MAHDI, & SAFEKORDI, ALI AKBAR. (2011). DRUG NANO-PARTICLES FORMATION BY SUPERCRITICAL RAPID EXPANSION METHOD; OPERATIONAL CONDITION EFFECTS INVESTIGATION. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), 30(1 (57)), 7-15. SID. https://sid.ir/paper/565942/en

    Vancouver: Copy

    ZABIHI FATEMEH, AKBARNEJAD MOHAMMAD MAHDI, VAZIRI YAZDI ALI, ARJOMAND MAHDI, SAFEKORDI ALI AKBAR. DRUG NANO-PARTICLES FORMATION BY SUPERCRITICAL RAPID EXPANSION METHOD; OPERATIONAL CONDITION EFFECTS INVESTIGATION. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE)[Internet]. 2011;30(1 (57)):7-15. Available from: https://sid.ir/paper/565942/en

    IEEE: Copy

    FATEMEH ZABIHI, MOHAMMAD MAHDI AKBARNEJAD, ALI VAZIRI YAZDI, MAHDI ARJOMAND, and ALI AKBAR SAFEKORDI, “DRUG NANO-PARTICLES FORMATION BY SUPERCRITICAL RAPID EXPANSION METHOD; OPERATIONAL CONDITION EFFECTS INVESTIGATION,” IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), vol. 30, no. 1 (57), pp. 7–15, 2011, [Online]. Available: https://sid.ir/paper/565942/en

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