SURVEY OF HEARING DISORDERS IN BETA THALASSEMIA MAJOR PATIENTS UNDER THERAPY WITH DESFERRIOXAMINE

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DOUSTI A.; AKHOUNDI REZA; ATIGHECHI S.

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Journal: VIRTUAL Year:621 | Volume:1 | Issue:1 Page(s): 56-56

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Title

SURVEY OF HEARING DISORDERS IN BETA THALASSEMIA MAJOR PATIENTS UNDER THERAPY WITH DESFERRIOXAMINE

Author(s)

DOUSTI A. | AKHOUNDI REZA | ATIGHECHI S.

Keywords

THALASSEMIA

SENSORINEURAL HEARING LOSS

DESFERRIOXAMINE

Abstract

Back ground: Beta thalassemia major (BTM) is the most common genetic anemia that because of the chronic hemolyzation, needs to inject blood frequently. In these patients desferrioxamine (DFO) is used to decrease the iron in blood. One of the complications of DFO is sensorineural hearing loss (SNHL). This research is to determine hearing loss in BTM.
Materials and Methods: In this analytic-descriptive research, all of the patients referring to Thalassemic Center of Yazd province between 2009-2010 were surveyed .Patients were evaluated with audiometry (HL=Hearing threshold ³ 20 dBHL), tympanometry .Exclusion criteria were: cases with ototoxic medications except DFO, past history of ear operation (myringotomy, ventilation tube, …) , the other diseases which affect hearing, abnormal physical exam (chronic otitis ,TM perforation,… ). 73 patients (35 female and 38 male) aged 6-40 years (mean 15/13 years) were enrolled. Variables include age, sex, and dosage and time consumption. Data were collected and analyzed with SPSS software.
Results: Out of 73 cases (146 ears), 63/01 % (46 people) had hearing loss (which 86/95% was SNHL). In tympanometry test, 91/8 % of ears had type AN. There was statically significant difference between hearing loss (HL) and dosage of DFO in frequency of 2000 Hz and also significant difference between HL and time consumption in frequency of 250 Hz. In high frequency (8000 Hz) in both ears, HL had significant difference. There was statically significant difference between Sexes (males more than females show HL). In cases with age more than 14 years, HL had significant difference in frequencies of 250, 500, 4000 Hz in compare to people whose age was lower than 14 years.
Discussion: In this study, the findings are indicative of DFO’s contributing role in the development of hearing impairment. Regular audiologic evaluation is imperative in all thalassemic patients so that early changes may be recognized .Time consumption and dosage of DFO should be control to prevent or reverse HL.

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APA: Copy

DOUSTI, A., AKHOUNDI, REZA, & ATIGHECHI, S.. (0). SURVEY OF HEARING DISORDERS IN BETA THALASSEMIA MAJOR PATIENTS UNDER THERAPY WITH DESFERRIOXAMINE. VIRTUAL, 1(1), 56-56. SID. https://sid.ir/paper/573124/en

Vancouver: Copy

DOUSTI A., AKHOUNDI REZA, ATIGHECHI S.. SURVEY OF HEARING DISORDERS IN BETA THALASSEMIA MAJOR PATIENTS UNDER THERAPY WITH DESFERRIOXAMINE. VIRTUAL[Internet]. 0;1(1):56-56. Available from: https://sid.ir/paper/573124/en

IEEE: Copy

A. DOUSTI, REZA AKHOUNDI, and S. ATIGHECHI, “SURVEY OF HEARING DISORDERS IN BETA THALASSEMIA MAJOR PATIENTS UNDER THERAPY WITH DESFERRIOXAMINE,” VIRTUAL, vol. 1, no. 1, pp. 56–56, 0, [Online]. Available: https://sid.ir/paper/573124/en

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