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Information Journal Paper

Title

FERULIC ACID LECITHIN-BASED NANO-EMULSIONS PREPARED BY USING SPONTANEOUS EMULSIFICATION PROCESS

Pages

  17-25

Keywords

MULTIPLE LINEAR REGRESSION (MLR) 
FERULIC ACID (FA) 

Abstract

 Ferulic acid (4-hydroxy-3-methoxycinnamic acid), an effective component of medical plant, is a phenolic acid with low toxicity that can be absorbed and easily metabolized in the human body. The solubility of Ferulic Acid (FA) is very low in aqueous solutions which can cause problem in preparation of pharmaceutical products, but it can easily be dissolved in oil/water interface of nano-emulsions. In the present work, a kind of ferulic acid nano-emulsion was prepared using the SPONTANEOUS EMULSIFICATION method which occurs when an organic phase and an aqueous phase are mixed. A chemometrics approach has been used to optimize the size of FA nanoemulsions. The experiments were performed according to a BOX-BEHENKEN EXPERIMENTAL DESIGN, one of the most suitable experimental design for modeling studies. The effect of three experimental parameters on droplet size was studied using multivariate analysis. The factors studied and the related levels were the concentration of lecithin (0.7-2 % w/w, in aqueous phase), the concentration of tween-80 (2-8 % w/w, in aqueous phase) and sounication time (10-45 minutes). In all the experiments, the water phase was added to the organic phase including lecithin, tween-80 and FA in ethanol solvent. Then experimental droplet sizes were fitted to the polynomial model. Good descriptive and predictive ability of the model was verified as high values of the statistics R2 (0.996) and F (112.5) were obtained for the linear relationship between predicted and experimental values of the dependent variable.

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    Cite

    APA: Copy

    EBRAHIMI, POUNEH, EBRAHIM MAGHAM, BAHAR, POURMORAD, FERESHTEH, & HONARY, SOHEILA. (2013). FERULIC ACID LECITHIN-BASED NANO-EMULSIONS PREPARED BY USING SPONTANEOUS EMULSIFICATION PROCESS. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), 32(3 (67)), 17-25. SID. https://sid.ir/paper/628505/en

    Vancouver: Copy

    EBRAHIMI POUNEH, EBRAHIM MAGHAM BAHAR, POURMORAD FERESHTEH, HONARY SOHEILA. FERULIC ACID LECITHIN-BASED NANO-EMULSIONS PREPARED BY USING SPONTANEOUS EMULSIFICATION PROCESS. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE)[Internet]. 2013;32(3 (67)):17-25. Available from: https://sid.ir/paper/628505/en

    IEEE: Copy

    POUNEH EBRAHIMI, BAHAR EBRAHIM MAGHAM, FERESHTEH POURMORAD, and SOHEILA HONARY, “FERULIC ACID LECITHIN-BASED NANO-EMULSIONS PREPARED BY USING SPONTANEOUS EMULSIFICATION PROCESS,” IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), vol. 32, no. 3 (67), pp. 17–25, 2013, [Online]. Available: https://sid.ir/paper/628505/en

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