ELECTRO SPINNING OF SILK FIBROIN/β-CYCLODEXTRIN NANO FIBERS FOR CONTROLLED DRUG RELEASE

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NOURI MAHDI; MOKHTARI JAVAD; SALMANI LEILA; SADEGHIEH KHATEREH

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Journal: Iranian Journal of Polymer Science and Technology Year:2016 | Volume:29 | Issue:1 (ISSUE NO.141) Page(s): 89-100

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Title

ELECTRO SPINNING OF SILK FIBROIN/β-CYCLODEXTRIN NANO FIBERS FOR CONTROLLED DRUG RELEASE

Author(s)

NOURI MAHDI | MOKHTARI JAVAD | SALMANI LEILA | SADEGHIEH KHATEREH | Issue Writer Certificate

Keywords

ELECTRO SPINNINGQ2

β-CYCLODEXTRINQ1

SILK FIBROINQ1

DRUG RELEASEQ2

NANO FIBERSQ2

Abstract

Silk fibroin (SF) as an important natural polymer has been extensively used as a suitable matrix in controlled DRUG RELEASE systems because of its biocompatibility feature, slow degradation rate and unique mechanical properties. In this study, a new b-cyclodextrin/silk fibroin nano fibrous membrane (b-CD/SF) with the function of molecular capture was successfully prepared by ELECTRO SPINNING of homogeneous solutions of b-CD and SF in formic acid. The effects of cyclodextrin on the NANO FIBERS properties and its DRUG RELEASE properties were investigated. The morphology, microscopic structure, chemical composition and heat treatment of the b-CD/SF nano fibrous membrane were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Scanning electronic microscopy images showed that defect free mats with a uniform structure were generated, and the average diameter of the NANO FIBERS was mainly affected by weight ratio of the blend. The result revealed that increasing the β-CD content in the blends lowered the average fiber diameter. In this report these observations are discussed with respect to the viscosity data of the ELECTRO SPINNING solutions which have been decreased with increasing b-cyclodextrin concentration. Differential scanning calorimetry results showed that drug was loaded into the b-cyclodextrin cavities. In vitro drug delivery profile of salicylic acid, as a drug model, was examined by UV spectroscopy at body temperature (37˚C) in phosphate buffer saline (pH 7.4). The molecular capturing ability of b-cyclodextrin/silk fibroin composite was improved with the amount of b-cyclodextrin in composite nano fibrous membrane which resulted in lower DRUG RELEASE.

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APA: Copy

NOURI, MAHDI, MOKHTARI, JAVAD, SALMANI, LEILA, & SADEGHIEH, KHATEREH. (2016). ELECTRO SPINNING OF SILK FIBROIN/β-CYCLODEXTRIN NANO FIBERS FOR CONTROLLED DRUG RELEASE. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), 29(1 (ISSUE NO.141)), 89-100. SID. https://sid.ir/paper/6349/en

Vancouver: Copy

NOURI MAHDI, MOKHTARI JAVAD, SALMANI LEILA, SADEGHIEH KHATEREH. ELECTRO SPINNING OF SILK FIBROIN/β-CYCLODEXTRIN NANO FIBERS FOR CONTROLLED DRUG RELEASE. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN)[Internet]. 2016;29(1 (ISSUE NO.141)):89-100. Available from: https://sid.ir/paper/6349/en

IEEE: Copy

MAHDI NOURI, JAVAD MOKHTARI, LEILA SALMANI, and KHATEREH SADEGHIEH, “ELECTRO SPINNING OF SILK FIBROIN/β-CYCLODEXTRIN NANO FIBERS FOR CONTROLLED DRUG RELEASE,” IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), vol. 29, no. 1 (ISSUE NO.141), pp. 89–100, 2016, [Online]. Available: https://sid.ir/paper/6349/en

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