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Information Journal Paper

Title

PRODUCTION AND EVALUATION OF LUTETIUM-177 MALTOLATE AS A POSSIBLE THERAPEUTIC AGENT

Pages

  61-67

Abstract

 Development of oral therapeutic radiopharmaceuticals is a new concept in radiopharmacy. Due to the interesting therapeutic properties of 177Lu and oral bioavailability of MALTOLATE (MAL) metal complexes, 177Lu-MALTOLATE (177Lu-MAL) was developed as a possible therapeutic compound for ultimate oral administration. The specific activity of 2.6-3 GBq/mg was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4×1013 n.cm-2.s-1 for LU-177. The product was converted into chloride form which was further used for labeling maltol (MAL). At optimized conditions a radiochemical purity of about >99% was obtained for 177Lu-MAL shown by ITLC (specific activity, 970-1000 Mbq/mmole). The stability of the labeled compound as well as the partition coefficient was determined in the final solution up to 24h. BIODISTRIBUTION studies of LU-177 chloride and 177Lu-MAL were carried out in wild-type rats for post-oral distribution phase data. Lu-MAL is a possible therapeutic agent in human malignancies for the bone palliation therapy so the efficacy of the compound should be tested in various animal models.

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    APA: Copy

    HAKIMI, A., JALILIAN, A.R., BAHRAMI SAMANI, A., & GHANNADI MARAGHEH, M.. (2012). PRODUCTION AND EVALUATION OF LUTETIUM-177 MALTOLATE AS A POSSIBLE THERAPEUTIC AGENT. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(2 (60-1)), 61-67. SID. https://sid.ir/paper/661689/en

    Vancouver: Copy

    HAKIMI A., JALILIAN A.R., BAHRAMI SAMANI A., GHANNADI MARAGHEH M.. PRODUCTION AND EVALUATION OF LUTETIUM-177 MALTOLATE AS A POSSIBLE THERAPEUTIC AGENT. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2012;-(2 (60-1)):61-67. Available from: https://sid.ir/paper/661689/en

    IEEE: Copy

    A. HAKIMI, A.R. JALILIAN, A. BAHRAMI SAMANI, and M. GHANNADI MARAGHEH, “PRODUCTION AND EVALUATION OF LUTETIUM-177 MALTOLATE AS A POSSIBLE THERAPEUTIC AGENT,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 2 (60-1), pp. 61–67, 2012, [Online]. Available: https://sid.ir/paper/661689/en

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