مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human 5637 Bladder Cancer Cells

Pages

  36-43

Abstract

 Royal jelly (RJ) as a traditional medicinal agent has a variety of pharmacological benefits. In the present study, the effects of the Royal jelly were investigated on the urinary Bladder Cancer cell line 5637 (HTB-9). MTT assay was performed to determine the percent of cell viability at different concentrations of the Royal jelly. Moreover, in vitro wound-healing assay was applied to investigate the effects of RJ on cell migration. The activities and gene expression levels of matrix metalloproteinase 2 and 9 were assessed by zymography and Real time PCR, respectively. It was confirmed that Royal jelly (RJ) at the concentration of 0. 7 mg/ml exerted a significant inhibitory effect on HTB 5637 cells and reduced cell viability to 72% in comparison to the control cultures (P-value<0. 009) during the first 72h of treatment. Furthermore, Royal jelly Significantly decreased the Bladder Cancerous cell migration capacity, and induced a significant decrease in the transcriptional level of the MMP9 after 72h (50% of the controls; Pvalue<0. 049). However, R. J. S did not impose any effect on the expression level and activity of matrix metalloproteinase 2. The results indicated the potential of RJ as a promising natural anti-proliferative and antimetastatic drug.

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    APA: Copy

    Fazili, Narges, SOHEILI, ZAHRA SOHEILA, MALEKZADEH SHAFAROUDI, SAEID, Sameie, Shahram, Alipoor, Shamila D., MOSHTAGHI, NASRIN, & BAGHERI, ABOUZAR. (2021). Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human 5637 Bladder Cancer Cells. JOURNAL OF CELL AND MOLECULAR RESEARCH, 13(1), 36-43. SID. https://sid.ir/paper/667701/en

    Vancouver: Copy

    Fazili Narges, SOHEILI ZAHRA SOHEILA, MALEKZADEH SHAFAROUDI SAEID, Sameie Shahram, Alipoor Shamila D., MOSHTAGHI NASRIN, BAGHERI ABOUZAR. Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human 5637 Bladder Cancer Cells. JOURNAL OF CELL AND MOLECULAR RESEARCH[Internet]. 2021;13(1):36-43. Available from: https://sid.ir/paper/667701/en

    IEEE: Copy

    Narges Fazili, ZAHRA SOHEILA SOHEILI, SAEID MALEKZADEH SHAFAROUDI, Shahram Sameie, Shamila D. Alipoor, NASRIN MOSHTAGHI, and ABOUZAR BAGHERI, “Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human 5637 Bladder Cancer Cells,” JOURNAL OF CELL AND MOLECULAR RESEARCH, vol. 13, no. 1, pp. 36–43, 2021, [Online]. Available: https://sid.ir/paper/667701/en

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