ESTIMATION OF PERMEABILITY USING MRJ AND SIMULATION OF CONTRAST AGENT CROSSING FROM ABNORMAL BLOOD BRAIN BARRIER

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YAHAGHI E.; SOLTANIANZADEH H.; SHAHRIARI M.; FATOURAEI N.; EWING J.

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Journal: AMIRKABIR Year:2005 | Volume:16 | Issue:62-A Page(s): 47-56

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Title

ESTIMATION OF PERMEABILITY USING MRJ AND SIMULATION OF CONTRAST AGENT CROSSING FROM ABNORMAL BLOOD BRAIN BARRIER

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Keywords

BLOOD BRAIN BARRIER (BBB)Q4

PERMEABILITYQ2

ARTERIAL INPUT FUNCTIONQ4

CONTRAST AGENTQ4

MONTE CARLO METHODQ4

Abstract

This work proposes a statistical approach for estimating blood brain barrier PERMEABILITY. The statistical model simulates crossing of CONTRAST AGENT according to PERMEABILITY and lesions of blood brain barrier (BBB). It considers crossing of CONTRAST AGENT through the capillary and BBB as intrinsically statistical processes and simulates it by MONTE CARLO METHOD. We extract real ARTERIAL INPUT FUNCTION (AIF) from magnetic resonance images (MRI) and consider it as input to the model. We then derive the concentration of CONTRAST AGENT as a function of time in the extra vascular space for abnormal capillary and different permabilities. Next, the real data is extracted from each pixel of rat brain. The curves of simulated and the real data of rat brain are compared and PERMEABILITY map of rat brain is obtained. The results of analytical method are compared to Monte Carlo simulation results. Because of error, permabilities estimated by the two methods are different. The advantages and error source of each method are explained. The main advantage of Monte Carlo simulation is its use of real data directly. It does not need curve fitting to real data, therefore, it is accurate and easy to use.

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APA: Copy

YAHAGHI, E., SOLTANIANZADEH, H., SHAHRIARI, M., FATOURAEI, N., & EWING, J.. (2005). ESTIMATION OF PERMEABILITY USING MRJ AND SIMULATION OF CONTRAST AGENT CROSSING FROM ABNORMAL BLOOD BRAIN BARRIER. AMIRKABIR, 16(62-A), 47-56. SID. https://sid.ir/paper/775/en

Vancouver: Copy

YAHAGHI E., SOLTANIANZADEH H., SHAHRIARI M., FATOURAEI N., EWING J.. ESTIMATION OF PERMEABILITY USING MRJ AND SIMULATION OF CONTRAST AGENT CROSSING FROM ABNORMAL BLOOD BRAIN BARRIER. AMIRKABIR[Internet]. 2005;16(62-A):47-56. Available from: https://sid.ir/paper/775/en

IEEE: Copy

E. YAHAGHI, H. SOLTANIANZADEH, M. SHAHRIARI, N. FATOURAEI, and J. EWING, “ESTIMATION OF PERMEABILITY USING MRJ AND SIMULATION OF CONTRAST AGENT CROSSING FROM ABNORMAL BLOOD BRAIN BARRIER,” AMIRKABIR, vol. 16, no. 62-A, pp. 47–56, 2005, [Online]. Available: https://sid.ir/paper/775/en

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