THE INCREASING EFFECT OF PRE-FEEDING WITH CUMIN EXTRACT ON THE PERMEABILITY OF THE BRAIN-BLOOD BARRIER CAUSED BY STROKE IN RATS

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MANSOURI M.; RAHNEMA M.; ESLAMI M.

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:13 | Issue:4 Page(s): 1-6

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Title

THE INCREASING EFFECT OF PRE-FEEDING WITH CUMIN EXTRACT ON THE PERMEABILITY OF THE BRAIN-BLOOD BARRIER CAUSED BY STROKE IN RATS

Author(s)

MANSOURI M. | RAHNEMA M. | ESLAMI M. | Issue Writer Certificate

Keywords

STROKEQ2

CUMINQ2

BLOOD-BRAIN BARRIERQ1

RATQ2

Abstract

Introduction: STROKE is the most important neurological disease and the third leading cause of death after coronary heart diseases and cancer in old people. Despite the many attempts for treating or understanding the pathophysiology of STROKEs, no effective treatments have yet been found for this accident. With the scientific name CUMINum cyminum, CUMIN has great medicinal benefits and is used in the treatment of different diseases. The present study was conducted to investigate the effectiveness of CUMIN extract in mitigating brain-blood barrier damage caused by STROKE.Methods & Materials: The present experimental study was conducted on five groups of six RATs, including one sham, one control and three trial groups. The trial groups received 25, 50 or 100 mg/kg of body weight oral dose of CUMIN extract for 30 days. Two hours after the last gavage, the control and trial groups underwent middle cerebral artery occlusion surgery to induce ischemia and their brain-blood barrier integrity was then measured.Results: No significant differences were observed in the concentration of Evans blue in the damaged cerebral hemisphere (the right hemisphere) between the trial groups that received 25 and 50 mg/kg doses of CUMIN extract and the control group. Nevertheless, a significant difference was observed in this concentration between the control group and the trial group that received an 100 mg/kg dose of the extract, as the concentration of Evans blue reduced in the right hemisphere with the administration of this dose of the extract (P<0.05).Conclusion: Pre-treatment with 100 mg/kg of body weight oral dose of CUMIN extract reduces the brain-blood barrier damage caused by STROKE.

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APA: Copy

MANSOURI, M., RAHNEMA, M., & ESLAMI, M.. (2016). THE INCREASING EFFECT OF PRE-FEEDING WITH CUMIN EXTRACT ON THE PERMEABILITY OF THE BRAIN-BLOOD BARRIER CAUSED BY STROKE IN RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 13(4), 1-6. SID. https://sid.ir/paper/130889/en

Vancouver: Copy

MANSOURI M., RAHNEMA M., ESLAMI M.. THE INCREASING EFFECT OF PRE-FEEDING WITH CUMIN EXTRACT ON THE PERMEABILITY OF THE BRAIN-BLOOD BARRIER CAUSED BY STROKE IN RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;13(4):1-6. Available from: https://sid.ir/paper/130889/en

IEEE: Copy

M. MANSOURI, M. RAHNEMA, and M. ESLAMI, “THE INCREASING EFFECT OF PRE-FEEDING WITH CUMIN EXTRACT ON THE PERMEABILITY OF THE BRAIN-BLOOD BARRIER CAUSED BY STROKE IN RATS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 13, no. 4, pp. 1–6, 2016, [Online]. Available: https://sid.ir/paper/130889/en

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