THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS

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REZAYOF A.; GOL HASANI KESHTAN F.; NAZARI SORANJEH F.; HAERI ROUHANI SEYED ALI

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Journal: ADVANCES IN COGNITIVE SCIENCE Year:2007 | Volume:9 | Issue:1 (33) Page(s): 1-9

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Title

THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS

Author(s)

REZAYOF A. | GOL HASANI KESHTAN F. | NAZARI SORANJEH F. | HAERI ROUHANI SEYED ALI | Issue Writer Certificate

Keywords

MORPHINEQ3

CONDITIONED PLACE PREFERENCEQ3

CENTRAL AMYGDALAQ3

NMDAQ3

MK-80LQ3

WISTAR RATSQ3

Abstract

Objective: In the present study, the effects of bilateral injections of N-methyl-D-aspartate (NMDA) receptor agonist and/or antagonist into the CENTRAL AMYGDALA (CeA) on the acquisition and expression of MORPHINE induced CONDITIONED PLACE PREFERENCE were investigated in male Wista rats. Method: Male WISTAR RATS (240-280g) were used in this research. The cannulas were implanted (bilaterally) in the (CeA) by stereotaxic instrument. All animals were allowed 1 week to recover before CPP. Unbiased CPP was induced using a. 5-day schedule consisted of pre-conditioning, conditioning and testing phases. Results: Animals that had received 3 daily subcutaneous (S.C.) injections of MORPHINE (1-9mg/kg) or saline (1ml/kg) showed a significant preference for compartment paired with MORPHINE in a dose dependent manner. Intra-CeA administration of the NMDA (0.01, 0.1 and 1mg/rat) with an ineffective dose of MORPHINE (1mg/kg, S.C.) elicited a significant CPP. Administration of the non-competitive NMDA receptor antagonist, MK-801 (0.1, 0.3 and 0.5mg/rat) into the CENTRAL AMYGDALA inhibited the MORPHINE (6mg/kg, s.c.)-induced place preference in a dose dependent manner. Furthermore, intra-CeA administration of MK-801 (0.25, 0.5 and 1mg/rat) reduced the response induced by NMDA (1mg/rat, intra-CeA) plus MORPHINE (1mg/kg, s.c.). Neither NMDA nor MK-801 alone did produce a significant place preference or place aversion. Moreover, intra-CeA injection of NMDA but not MK-801 before testing significantly increased the expression of MORPHINE (6mg/kg, s.c.)-induced place preference. Conclusion: These results suggest that the glutamatergic system through the NMDA receptor mechanisms in the CENTRAL AMYGDALA may play an important role in the acquisition and expression of MORPHINE-induced place preference.

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APA: Copy

REZAYOF, A., GOL HASANI KESHTAN, F., NAZARI SORANJEH, F., & HAERI ROUHANI, SEYED ALI. (2007). THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS. ADVANCES IN COGNITIVE SCIENCE, 9(1 (33)), 1-9. SID. https://sid.ir/paper/82994/en

Vancouver: Copy

REZAYOF A., GOL HASANI KESHTAN F., NAZARI SORANJEH F., HAERI ROUHANI SEYED ALI. THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2007;9(1 (33)):1-9. Available from: https://sid.ir/paper/82994/en

IEEE: Copy

A. REZAYOF, F. GOL HASANI KESHTAN, F. NAZARI SORANJEH, and SEYED ALI HAERI ROUHANI, “THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS,” ADVANCES IN COGNITIVE SCIENCE, vol. 9, no. 1 (33), pp. 1–9, 2007, [Online]. Available: https://sid.ir/paper/82994/en

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