EXTENDED FREQUENCY SWEEP: A MORE REALISTIC RHEOLOGICAL APPROACH TO INVESTIGATE THE PROCESS OF MUCOADHESIVE POLYMER-MUCUS GEL CHAIN INTERPENETRATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MORTAZAVI S.A.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2003 | Volume:12 | Issue:5 Page(s): 413-420

Download Full-Text

Persian Verion

View:

969

Download:

287

Cites:

Information Journal Paper

Title

EXTENDED FREQUENCY SWEEP: A MORE REALISTIC RHEOLOGICAL APPROACH TO INVESTIGATE THE PROCESS OF MUCOADHESIVE POLYMER-MUCUS GEL CHAIN INTERPENETRATION

Author(s)

MORTAZAVI S.A.R. | Issue Writer Certificate

Keywords

BIORHEOLOGYQ4

CARBOPOLSQ4

MUCOADHESIONQ4

MUCOADHESIVE POLYMERSQ4

DYNAMIC OSCILLATORY RHEOLOGYQ4

Abstract

Mucoadhesive formulations have been of great interest in recent years. One approach to study MUCOADHESION is the technique of DYNAMIC OSCILLATORY RHEOLOGY (DOR). In this study the use of an extended frequency sweep DOR, instead of the routine limited DOR studies, as a more comprehensive and realistic mean of investigating the process of MUCOADHESION was investigated. For this purpose polymeric discs were directly placed in contact with natural mucus samples and incubated for various time intervals (15, 60 and 120 min) at 37°C, and then rheologically examined across a frequency of 0.0001 - 10 Hz. Results showed that in the presence of anionic mucoadhesive discs containing Carbopol 934P (C934) and sodium carboxymethyl cellulose (NaCMC), the G (storage modulus) and to a smaller extent G" (loss modulus) values of the weakly viscoelastic mucus samples are strengthened much more than the non-ionic polymer hydroxypropyl cellulose and the calcium containing Carbopol EX83, and far less reduced at frequencies below 1Hz. However, in the presence of potassium thiocyanate (hydrogen-bond breaking agent), unlike G" values, the G values of particularly the anionic polymers C934 and NaCMC suffered a sharp decline at frequencies below 1Hz. These findings support the theory of mucoadhesive polymer chain interpenetration and formation of hydrogen-bonds with the mucus gel network, and shows that by using an extended frequency sweep rather than a normal limited frequency sweep, a more detailed and realistic approach for studying the process of MUCOADHESION and putative MUCOADHESIVE POLYMERS and formulations, could be provided.

Cites

No record.

References

No record.

Cite

APA: Copy

MORTAZAVI, S.A.R.. (2003). EXTENDED FREQUENCY SWEEP: A MORE REALISTIC RHEOLOGICAL APPROACH TO INVESTIGATE THE PROCESS OF MUCOADHESIVE POLYMER-MUCUS GEL CHAIN INTERPENETRATION. IRANIAN POLYMER JOURNAL (ENGLISH), 12(5), 413-420. SID. https://sid.ir/paper/85897/en

Vancouver: Copy

MORTAZAVI S.A.R.. EXTENDED FREQUENCY SWEEP: A MORE REALISTIC RHEOLOGICAL APPROACH TO INVESTIGATE THE PROCESS OF MUCOADHESIVE POLYMER-MUCUS GEL CHAIN INTERPENETRATION. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2003;12(5):413-420. Available from: https://sid.ir/paper/85897/en

IEEE: Copy

S.A.R. MORTAZAVI, “EXTENDED FREQUENCY SWEEP: A MORE REALISTIC RHEOLOGICAL APPROACH TO INVESTIGATE THE PROCESS OF MUCOADHESIVE POLYMER-MUCUS GEL CHAIN INTERPENETRATION,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 12, no. 5, pp. 413–420, 2003, [Online]. Available: https://sid.ir/paper/85897/en

Related Journal Papers