AN INVESTIGATION INTO THE EFFECT OF DEHYDRATION BY MUCOADHESIVE POLYMERS ON THE RESULTING HANGES IN THE VISCOELASTIC STRUCTURE OF THE MUCUS GEL

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MORTAZAVI S.A.A.GH.

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Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:2 Page(s): 11-22

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Title

AN INVESTIGATION INTO THE EFFECT OF DEHYDRATION BY MUCOADHESIVE POLYMERS ON THE RESULTING HANGES IN THE VISCOELASTIC STRUCTURE OF THE MUCUS GEL

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MORTAZAVI S.A.A.GH. | Issue Writer Certificate

Keywords

MUCOADHESIONQ3

MUCOADHESIVE POLYMERSQ3

MUCUS DEHYDRATIONQ3

RHEOLOGIC BEHAVIORQ3

DYNAMIC OSCILLATORY RHEOLOGYQ3

Abstract

Among the proposed theories of MUCOADHESION is the theory of MUCUS DEHYDRATION by the mucoadhesive polymer and the theory of polymer chain interpenetration into the mucus gel network, followed by the formation of weak bonds between them. These theories look at the process of MUCOADHESION from their own point of view. In this study, it was decided to consider the two theories alongside each other, and to investigate the effect of MUCUS DEHYDRATION by MUCOADHESIVE POLYMERS on the viscoelastic structure of mucus gel. For this purpose polymeric discs (each containing only one polymer) containing carbomer 934 (C934), sodium carboxymethyl cellulose, hydroxypropyl cellulose (HPC), sodium alginate and tragacanth were prepared and placed in contact with the mucus gel for a period of 480 min within sealed containers at 37°C. At set intervals mucus gel was carefully separated from polymeric discs, re-weighed, and their G' (storage modulus) and G" (loss modulus) determined using DYNAMIC OSCILLATORY RHEOLOGY at a frequency of oscillation between 0.1-10 Hz. Data obtained showed that the dehydration of mucus resulted in the strengthening of the viscoelastic structure of the mucus gel. Furthermore, beside MUCUS DEHYDRATION, polymer chains should be able to desirably penetrate into the glycoprotein chains of the mucus gel and as a result increase elasticity or in another word G", much more than G". In here the non-ionic polymer HPC performed much weaker than the anionic polymers investigated. On the other hand C934, which has dehydrated the mucus gel less than the other three anionic polymers, resulted in the greatest strengthening of the mucus gel structure. Hence, it appears that the collateral consideration of the two mentioned theories could explain the - process of MUCOADHESION more appropriately.

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APA: Copy

MORTAZAVI, S.A.A.GH.. (2004). AN INVESTIGATION INTO THE EFFECT OF DEHYDRATION BY MUCOADHESIVE POLYMERS ON THE RESULTING HANGES IN THE VISCOELASTIC STRUCTURE OF THE MUCUS GEL. PHARMACEUTICAL SCIENCES, -(2), 11-22. SID. https://sid.ir/paper/48477/en

Vancouver: Copy

MORTAZAVI S.A.A.GH.. AN INVESTIGATION INTO THE EFFECT OF DEHYDRATION BY MUCOADHESIVE POLYMERS ON THE RESULTING HANGES IN THE VISCOELASTIC STRUCTURE OF THE MUCUS GEL. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(2):11-22. Available from: https://sid.ir/paper/48477/en

IEEE: Copy

S.A.A.GH. MORTAZAVI, “AN INVESTIGATION INTO THE EFFECT OF DEHYDRATION BY MUCOADHESIVE POLYMERS ON THE RESULTING HANGES IN THE VISCOELASTIC STRUCTURE OF THE MUCUS GEL,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 11–22, 2004, [Online]. Available: https://sid.ir/paper/48477/en

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