THE EFFECT OF TYPE AND AMOUNT OF POLYMER ON THE BIOADHESIVE PROPERTIES AND DRUG RELEASE OF DICLOFENAC SODIUM BUCCOADHESIVE FILMS

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AKBARI JAFAR; SAEEDI MAJID; MORTEZA SEMNANI KATAYOUN; AMERI MASOOD

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Journal: Journal of Mazandaran University of Medical Sciences Year:2014 | Volume:24 | Issue:113 Page(s): 92-103

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Title

THE EFFECT OF TYPE AND AMOUNT OF POLYMER ON THE BIOADHESIVE PROPERTIES AND DRUG RELEASE OF DICLOFENAC SODIUM BUCCOADHESIVE FILMS

Author(s)

AKBARI JAFAR | SAEEDI MAJID | MORTEZA SEMNANI KATAYOUN | AMERI MASOOD | Issue Writer Certificate

Keywords

BUCCAL FILMQ2

MUCOADHESIVEQ3

DICLOFENACQ2

EUDRAGIT L100-55Q2

Abstract

Background and purpose: Buccal delivery of drug provides an attractive alternative to the oral route of drug administration and a convenient route of administration for both systemic and local drug delivery. Absorption of therapeutic agents from the oral cavity provides a direct entry for such agents into the systemic circulation, thereby avoiding first-pass metabolism and gastrointestinal degradation. The objective of this study was to develop and characterize MUCOADHESIVE BUCCAL FILMs from DICLOFENAC sodium.Material and Methods: BUCCAL FILMs containing DICLOFENAC sodium were prepared using solvent casting method. EUDRAGIT L100-55 was used as film forming polymer, and HPMC K4M and PVP K25 were used as MUCOADHESIVE polymers. The effect of type and amount of polymer on drug release rate, swelling and erosion rate and the Mucoadhesion strength were evaluated.Results: HPMC K4M decreased the rate of drug release but adding PVP K25 increased the drug release. Adding hydrophilic polymers such as HPMC K4M, and PVP K25, significantly increased the swelling percentage. Moreover, increase in HPMC K4M amount, decreased the erosion percentage and increased the MUCOADHESIVE strength.Conclusion: Eudragit BUCCAL FILMs can be successfully used as a MUCOADHESIVE carrier in buccal drug delivery systems for drugs with high first-pass metabolism. Also, this study proved the effect of hydrophilic polymers on drug release profile and other properties of the films.

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APA: Copy

AKBARI, JAFAR, SAEEDI, MAJID, MORTEZA SEMNANI, KATAYOUN, & AMERI, MASOOD. (2014). THE EFFECT OF TYPE AND AMOUNT OF POLYMER ON THE BIOADHESIVE PROPERTIES AND DRUG RELEASE OF DICLOFENAC SODIUM BUCCOADHESIVE FILMS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(113), 92-103. SID. https://sid.ir/paper/45313/en

Vancouver: Copy

AKBARI JAFAR, SAEEDI MAJID, MORTEZA SEMNANI KATAYOUN, AMERI MASOOD. THE EFFECT OF TYPE AND AMOUNT OF POLYMER ON THE BIOADHESIVE PROPERTIES AND DRUG RELEASE OF DICLOFENAC SODIUM BUCCOADHESIVE FILMS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(113):92-103. Available from: https://sid.ir/paper/45313/en

IEEE: Copy

JAFAR AKBARI, MAJID SAEEDI, KATAYOUN MORTEZA SEMNANI, and MASOOD AMERI, “THE EFFECT OF TYPE AND AMOUNT OF POLYMER ON THE BIOADHESIVE PROPERTIES AND DRUG RELEASE OF DICLOFENAC SODIUM BUCCOADHESIVE FILMS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 113, pp. 92–103, 2014, [Online]. Available: https://sid.ir/paper/45313/en

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