CYTOTOXIC EFFECT OF PROPRANOLOL ON HUMAN LEUKEMIC MOLT-4 CELL LINE

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HAJI GHASEMI FATEMEH; MIRSHAFIEI A.; POURPAK Z.

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Seminar Paper

Paper Information

Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Year:2007 | Issue:6

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Title

CYTOTOXIC EFFECT OF PROPRANOLOL ON HUMAN LEUKEMIC MOLT-4 CELL LINE

Author(s)

HAJI GHASEMI FATEMEH | MIRSHAFIEI A. | POURPAK Z.

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Abstract

Introduction: Propranolol, a beta-adrenergic blocker has been used for the treatment of a large number of cardiovascular diseases. This drug is also an inhibitor of phosphatidic acid (PA) phosphohydrolase and phosphatidic acid biosynthesis. Phosphatidic acid is a growth factor for tumor cells. In addition, the inhibitory effects of Propranolol on the development of a tobacco-induced pulmonary adenocarcinoma and also its cytotoxicity on rat and human lung macrophages and human lung tumor cell line have been reported. The widespread and long-term use of propranolol in lots of heart diseases as well as its cytotoxicity against some tumor cells prompted us to investigate its cytotoxic effect on a human T leukemic cell line (MOLT-4).Materials and Methods: The MOLT-4 cells were cultured in complete RPMI medium and then incubated with different concentrations of Propranolol (0.0004 -0.4mM) for 10 and 20 hours. The cytotoxicity was then assessed by 3-[4,5-dimethyl thiazol-2,5-diphenyltetrazoliumbromide (MTT) reduction and also trypan blue dye exclusion methods.Results: Propranolol induced a significant dose-dependent cytotoxic effect on human MOLT-4 cell line in less than 10 hours compared to untreated control cells.Discussion: The results showed that human T leukemic cell line was dose-dependently-sensitive to Propranolol. Further studies investigating the in vivo effect of Propranolol on leukemic patients and also other leukemic cells are warranted.

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APA: Copy

HAJI GHASEMI, FATEMEH, MIRSHAFIEI, A., & POURPAK, Z.. (2007). CYTOTOXIC EFFECT OF PROPRANOLOL ON HUMAN LEUKEMIC MOLT-4 CELL LINE. BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. SID. https://sid.ir/paper/902554/en

Vancouver: Copy

HAJI GHASEMI FATEMEH, MIRSHAFIEI A., POURPAK Z.. CYTOTOXIC EFFECT OF PROPRANOLOL ON HUMAN LEUKEMIC MOLT-4 CELL LINE. 2007. Available from: https://sid.ir/paper/902554/en

IEEE: Copy

FATEMEH HAJI GHASEMI, A. MIRSHAFIEI, and Z. POURPAK, “CYTOTOXIC EFFECT OF PROPRANOLOL ON HUMAN LEUKEMIC MOLT-4 CELL LINE,” presented at the BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. 2007, [Online]. Available: https://sid.ir/paper/902554/en

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