GABAPENTIN ENHANCES THE ANALGESIC RESPONSE TO MORPHINE IN TAIL FLICK TEST IN MALE RATS

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SEPEHRI GH.R.; SHAMSI MEYMANDI M.; MOBASHER M.; MOHAMMADI RAZIEH; MAHALATI A.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

GABAPENTIN ENHANCES THE ANALGESIC RESPONSE TO MORPHINE IN TAIL FLICK TEST IN MALE RATS

Author(s)

SEPEHRI GH.R. | SHAMSI MEYMANDI M. | MOBASHER M. | MOHAMMADI RAZIEH | MAHALATI A.

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Abstract

Introduction: Opioids as drug of choice in acute pain treatment result in inadequate analgesia and side effects. Therefore the combinational therapy of other drugs with opioids could decrease the side effects, tolerance and opioid dependency. So in this study the effect of gabapentin & morphine co administration is evaluated in acute model of pain. Methods: The antinociceptive effect of gabapentin (30 or 90mg/kg, s.c.) and morphine (0.5,1 & 3mg/kg,s.c.) alone or in combination with gabapentin were measured by Tail-flick test each 15 min for 105 min in intact adult male rats. Control rats received normal saline. Area Under Curve (AUC), as antinociceptive index, was calculated for each groups. Results: Both gabapentin (90mg/kg) and morphine(1 & 3 mg/kg) showed antinociceptive response as compared to controls (P<0.05).But there was not any significant differences between the (AUC) of 0.5mg/kg morphine and 30mg/kg gabapentin as compared to controls, so these doses were considered as subanalgesic doses. The co-administration of subanalgesic doses of morphine (0.5mg/kg) & gabapentin (30mg/kg) increased significantly AUC as compared to morphine alone (P<0.001). The co administration of gabapentin(30 & 90mg/kg) with analgesic doses of 1mg/kg (P<0.005) and 3mg/kg morphine had also increased significantly AUC antinociceptive index as compared to controls (P<0.05).Conclusion: Gabapentin enhanced the antinociceptive effect of both analgesic and subanalgesic doses of morphine in a dose dependent manner in acute pain model in male rats.

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APA: Copy

SEPEHRI, GH.R., SHAMSI MEYMANDI, M., MOBASHER, M., MOHAMMADI, RAZIEH, & MAHALATI, A.. (2007). GABAPENTIN ENHANCES THE ANALGESIC RESPONSE TO MORPHINE IN TAIL FLICK TEST IN MALE RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903066/en

Vancouver: Copy

SEPEHRI GH.R., SHAMSI MEYMANDI M., MOBASHER M., MOHAMMADI RAZIEH, MAHALATI A.. GABAPENTIN ENHANCES THE ANALGESIC RESPONSE TO MORPHINE IN TAIL FLICK TEST IN MALE RATS. 2007. Available from: https://sid.ir/paper/903066/en

IEEE: Copy

GH.R. SEPEHRI, M. SHAMSI MEYMANDI, M. MOBASHER, RAZIEH MOHAMMADI, and A. MAHALATI, “GABAPENTIN ENHANCES THE ANALGESIC RESPONSE TO MORPHINE IN TAIL FLICK TEST IN MALE RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/903066/en

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