HYPEROXIA INDUCED PROTECTION AGAINST RAT'S RENAL ISCHEMIC DAMAGE: RELATION TO OXYGEN EXPOSURE TIME

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VAHAB AGHAEI H.; RASOULIAN B.; ESMAEILI DEHAJ MANSOUR; MEHRANI H.A.; MOHAMMAD HOSSEIN AKBARI HASAN; KHOUSHBATEN A.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

HYPEROXIA INDUCED PROTECTION AGAINST RAT'S RENAL ISCHEMIC DAMAGE: RELATION TO OXYGEN EXPOSURE TIME

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Keywords

IR INJURY

HYPEROXIA

PRECONDITIONING

ANTIOXIDANT SYSTEM

Abstract

Pre-exposure to hyperoxic gas (95%) has been shown to protect the heart and central nervous system from ischemia-reperfusion injury. In the present study we investigated whether oxygen pretreatment induces delayed renal protection in rats. The possible role of some renal antioxidant agents was also investigated. Adult male Wistar rats were kept in a hyperoxic (HO) (95% O2) environment for 0.5h, 1h, 2h, 3h, 6h, 2h/day for 3 consecutive days and 4h/day for 6 consecutive days and control group (IR) animals were kept in the cage with no HO; one day before subjecting their kidney to 40 minutes of ischemia and 24h of reperfusion. Renal function was assessed by comparing plasma creatinine (Cr), blood urea nitrogen (BUN), creatinine clearance (CLCr) and fractional excretion of sodium (FENa%). Histopathological injury score was also determined according to Jablonski method. To examine the antioxidant system induction by hyperoxia we measured renal catalase and superoxide dismutase activity and renal glutathione and malondialdehyde content. Our data demonstrated that only in 4h/day HO for 6 consecutive days the renal function tests (Cr, CLCr, BUN and FENa%) and Jablonski histological injury were better than control group (p<0.05). The beneficial effect of oxygen pretreatment in this group was associated with increased renal catalase activity compared with those obtained from control group (p<0.05). These findings suggest that repeated exposure to hyperoxic (95% O2) environment can reduce subsequent rat's renal ischemia-reperfusion damage. Induction of endogenous antioxidant system may partially explain this beneficial effect of hyperoxic preconditioning.

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APA: Copy

VAHAB AGHAEI, H., RASOULIAN, B., ESMAEILI DEHAJ, MANSOUR, MEHRANI, H.A., MOHAMMAD HOSSEIN AKBARI, HASAN, & KHOUSHBATEN, A.. (2009). HYPEROXIA INDUCED PROTECTION AGAINST RAT'S RENAL ISCHEMIC DAMAGE: RELATION TO OXYGEN EXPOSURE TIME. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903594/en

Vancouver: Copy

VAHAB AGHAEI H., RASOULIAN B., ESMAEILI DEHAJ MANSOUR, MEHRANI H.A., MOHAMMAD HOSSEIN AKBARI HASAN, KHOUSHBATEN A.. HYPEROXIA INDUCED PROTECTION AGAINST RAT'S RENAL ISCHEMIC DAMAGE: RELATION TO OXYGEN EXPOSURE TIME. 2009. Available from: https://sid.ir/paper/903594/en

IEEE: Copy

H. VAHAB AGHAEI, B. RASOULIAN, MANSOUR ESMAEILI DEHAJ, H.A. MEHRANI, HASAN MOHAMMAD HOSSEIN AKBARI, and A. KHOUSHBATEN, “HYPEROXIA INDUCED PROTECTION AGAINST RAT'S RENAL ISCHEMIC DAMAGE: RELATION TO OXYGEN EXPOSURE TIME,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903594/en

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