CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?

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MOUSAVI MARYAM; GHASEMI RASOUL; MAGHSOUDI NADER; RASTGARI KARIM; ZARIFKAR ASAD ELAH

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?

Author(s)

MOUSAVI MARYAM | GHASEMI RASOUL | MAGHSOUDI NADER | RASTGARI KARIM | ZARIFKAR ASAD ELAH

Keywords

PREGNANCY

IMMOBILIZATION STRESS

APOPTOSIS

RAT

HIPPOCAMPUS

Abstract

Stress has been reported to elevate glucocorticoids and to deteriorate hippocampal function and viability. Some studies suggest that IMMOBILIZATION STRESS results in hippocampal APOPTOSIS in male RATs. On the other hand, it has been suggested that pregnant RATs are more resistant to neurodegeneration. In this study, we evaluated whether acute and chronic IMMOBILIZATION STRESS can change glucocorticoid levels and hippocampal viability in pregnant RATs. RATs were immobilized from day 14-19 of PREGNANCY in a restrainer; 1 or 3 hours each day (chronic stress) or just one episode on day 14 (acute stress). RATs were sacrificed after the last stress episode; blood samples were collected to determine corticosterone level. The hippocampi were collected, lysed and anlaysed via western blot to assess caspase 3 cleavage. IMMOBILIZATION STRESS elevated corticosterone level, but did not induce APOPTOSIS. It seems that pregnant RATs are more resistant to stress than the male RATs.

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APA: Copy

MOUSAVI, MARYAM, GHASEMI, RASOUL, MAGHSOUDI, NADER, RASTGARI, KARIM, & ZARIFKAR, ASAD ELAH. (2009). CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903653/en

Vancouver: Copy

MOUSAVI MARYAM, GHASEMI RASOUL, MAGHSOUDI NADER, RASTGARI KARIM, ZARIFKAR ASAD ELAH. CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?. 2009. Available from: https://sid.ir/paper/903653/en

IEEE: Copy

MARYAM MOUSAVI, RASOUL GHASEMI, NADER MAGHSOUDI, KARIM RASTGARI, and ASAD ELAH ZARIFKAR, “CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903653/en

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