AIRWAY RESPONSIVENESS TO SALBUTAMOL IN COPD PATIENTS

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BOSKABADI M.H.; MANSOURI FARIBA; SHAFEI M.N.; BOSKABADI M.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

AIRWAY RESPONSIVENESS TO SALBUTAMOL IN COPD PATIENTS

Author(s)

BOSKABADI M.H. | MANSOURI FARIBA | SHAFEI M.N. | BOSKABADI M.

Keywords

COPD

SALBUTAMOL

AIRWAY HYPERRESPONSIVENESS

Abstract

Airway hyperresponsiveness (AHR) is the most characteristic feature of asthma, which is reported in COPD patients and smoker subjects. Increased airway responsiveness to b-agonists is also demonstrated in asthmatic and smoker subjects. However, there is no report regarding AHR to b-agonist drugs in COPD patients. Therefore, in this study airway responsiveness to salbutamol in COPD patients was examined. The threshold concentrations of inhaled salbutamol required for a 20% change in forced expiratory flow in 1 sec (FEV1) as PC20, or a 35% change in specific airway conductance (sGaw) as PC35 was measured in 14 COPD patients and 14 normal subjects. Airway responsiveness to salbutamol in COPD patients (PC20= 14.14±1.62 and PC35=9.70±1.48 mg/l) was significantly higher (PC20 and were PC35 lower) than normal subjects (PC20= 224.57±16.62 and PC35=81.87±8.16 mg/l, P<0.001 for both cases). The values of FEV1 and sGaw in COPD patients (56.43±14.45 and 0.081±0.120 respectively) were significantly lower than those of normal subjects (104.07±5.72 and 0.194±0.041 respectively), (p<0.001 for FEV1 and p<0.005 for sGaw). There was a significant correlation between FEV1 with PC20 salbutamol (r=0.862, p<0.001). The correlations between PC20 and PC35 was also statistically significant (r=0.862, p<0.001). In conclusion, these results showed increased airway responsiveness of most COPD patients to salbutamol which was correlated with airway caliber.

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APA: Copy

BOSKABADI, M.H., MANSOURI, FARIBA, SHAFEI, M.N., & BOSKABADI, M.. (2009). AIRWAY RESPONSIVENESS TO SALBUTAMOL IN COPD PATIENTS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903738/en

Vancouver: Copy

BOSKABADI M.H., MANSOURI FARIBA, SHAFEI M.N., BOSKABADI M.. AIRWAY RESPONSIVENESS TO SALBUTAMOL IN COPD PATIENTS. 2009. Available from: https://sid.ir/paper/903738/en

IEEE: Copy

M.H. BOSKABADI, FARIBA MANSOURI, M.N. SHAFEI, and M. BOSKABADI, “AIRWAY RESPONSIVENESS TO SALBUTAMOL IN COPD PATIENTS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903738/en

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