WATER EXTRACT OF SAFFRON (CROCUS SATIVUS) INHIBITS CHRONIC PHASE OF FORMALINE TEST IN FEMALE MICE

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RIAHI SIMIN; IZADI H.R.; GHOSHOUNI H.; SAHRAEI HEDAYAT

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

WATER EXTRACT OF SAFFRON (CROCUS SATIVUS) INHIBITS CHRONIC PHASE OF FORMALINE TEST IN FEMALE MICE

Author(s)

RIAHI SIMIN | IZADI H.R. | GHOSHOUNI H. | SAHRAEI HEDAYAT

Keywords

CROCUS SATIVUS

ANALGESIA

FORMALIN TEST

NITRIC OXIDE

NMDA GLUTAMATE RECEPTORS

Abstract

Previous investigations confirmed the effectiveness of water-alcoholic saffron extract in analgesia and inflammation inhibition in mice. In the present study, the anticocieceptive activity of saffron water-extract in female N-MARI mice (20-25 g) was investigated. Formalin test was applied for pain assessment. 30 min before 2% formalin solution (2μlit) in posterior plantar angle injection, the drugs were administered to the animals. Then the animals were evaluated for pain assessment for 60 min in a 5 min inter walls manner. Morphine (1, 5 and 10 mg/kg) administration induced antinocieception in both acute and chronic phases of formalin test in a dose-dependent manner. Extract (10, 50 1nd 100 mg/kg) also induced analgesia in chronic but not acute phase of formalin test. Naloxone (4 mg/kg) administration had no effect on the antinocieceptive activity of the extract. Dextromethorphane (20 mg/kg), on the other hand, enhances the extract action in acute phase as well as chronic phase. In addition, L-NAME (10 mg/kg) administration potentiated the extract effect. Co-administration of ineffective dose of indomethacine (2.5 mg/kg) with the extract (2.5 mg/kg) had no influence on the extract anticocieception effect. It could be concluded from these experiments that water extract of C sativus exerts its effect on the chronic phase of formalin test possibly via inhibition of NMDA glutamatergic as well as nitric oxide system.

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APA: Copy

RIAHI, SIMIN, IZADI, H.R., GHOSHOUNI, H., & SAHRAEI, HEDAYAT. (2009). WATER EXTRACT OF SAFFRON (CROCUS SATIVUS) INHIBITS CHRONIC PHASE OF FORMALINE TEST IN FEMALE MICE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903777/en

Vancouver: Copy

RIAHI SIMIN, IZADI H.R., GHOSHOUNI H., SAHRAEI HEDAYAT. WATER EXTRACT OF SAFFRON (CROCUS SATIVUS) INHIBITS CHRONIC PHASE OF FORMALINE TEST IN FEMALE MICE. 2009. Available from: https://sid.ir/paper/903777/en

IEEE: Copy

SIMIN RIAHI, H.R. IZADI, H. GHOSHOUNI, and HEDAYAT SAHRAEI, “WATER EXTRACT OF SAFFRON (CROCUS SATIVUS) INHIBITS CHRONIC PHASE OF FORMALINE TEST IN FEMALE MICE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903777/en

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