THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN THE ANTICONVULSANT EFFECT OF ACUTE LITHIUM CHOLORIDE ADMINISTRATION IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE

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BAHREMAND ARASH; ZIAEI P.; PAYANDEH MEHR B.; DEHPOUR A.R.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN THE ANTICONVULSANT EFFECT OF ACUTE LITHIUM CHOLORIDE ADMINISTRATION IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE

Author(s)

BAHREMAND ARASH | ZIAEI P. | PAYANDEH MEHR B. | DEHPOUR A.R.

Keywords

LITHIUM CHLORIDE

NO SYSTEM

SEIZURE

PTZ

MICE

Abstract

Objective: Lithium is mainly used in the treatment of affective disorders as a mood stabilizer. Lithium also shows anticonvulsant properties in clinic and lab. It is now clear that some of lithium effects are mediation by nitric oxide-cGMP pathway. In this study we Used a model of clonic seizure to investigate whether these anticonvulsant effects are mediated through NOcGMP pathway.Methods: Male NMRI mice (23-30 gr) were used. In order to measure the seizure threshold PTZ (0.5 %) was infused in to the tail vein of freely moving animal with constant rate of 1 mi/min. All drugs were administered (i.p) and 15 minutes before appropriate dose of lithium and 75 min before inducing seizure by i.v. injection of pentylenetetrazole.Results: Injection of a single effective dose of lithium chloride (25mg/kg, i.p.) significantly increased the seizure threshold (p< 0.01) in comparison with controls .This anticonvulsant effect was prevented by pretreatment with the per se non-effective dose of L-ARG (100 and 200 mg/kg, i.p.).But administration of low doses of non-specific NOS inhibitor L-NAME (15 and 30 mg/kg, i.p.) which were independently non-effective, potentiated sub-effective doses of lithium (10 mg/kg) significantly. Several doses of inducible NOS inhibitor aminoguanidine failed to alter the anticonvulsant effect of lithium, excluding the role of iNOS in this phenomenon. Finally, anticonvulsant effect of a potent dose of lithium was inhibited by pretreatment with sildenafil (5 mg/kg i.p.) which emphasizes on the role of NO-cGMP pathway in conducting the anticonvulsant effect of lithium chloride.Conclusions: NO-cGMP pathway is involved in the anticonvulsant properties of the lithium chloride. Also, the role of cNOS against iNOS is prominent in this phenomenon.

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APA: Copy

BAHREMAND, ARASH, ZIAEI, P., PAYANDEH MEHR, B., & DEHPOUR, A.R.. (2009). THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN THE ANTICONVULSANT EFFECT OF ACUTE LITHIUM CHOLORIDE ADMINISTRATION IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903794/en

Vancouver: Copy

BAHREMAND ARASH, ZIAEI P., PAYANDEH MEHR B., DEHPOUR A.R.. THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN THE ANTICONVULSANT EFFECT OF ACUTE LITHIUM CHOLORIDE ADMINISTRATION IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE. 2009. Available from: https://sid.ir/paper/903794/en

IEEE: Copy

ARASH BAHREMAND, P. ZIAEI, B. PAYANDEH MEHR, and A.R. DEHPOUR, “THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN THE ANTICONVULSANT EFFECT OF ACUTE LITHIUM CHOLORIDE ADMINISTRATION IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903794/en

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