THE EFFECT OF DIZOCILPINE (MK-801) IN NEUROTOXICITY INDUCED BY PARAOXON IN HIPPOCAMPAL CELL CULTHURE OF RAT

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BAHRAMI FARIDEH; YOUSEFPOUR MITRA

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

THE EFFECT OF DIZOCILPINE (MK-801) IN NEUROTOXICITY INDUCED BY PARAOXON IN HIPPOCAMPAL CELL CULTHURE OF RAT

Author(s)

BAHRAMI FARIDEH | YOUSEFPOUR MITRA

Keywords

PARAOXON

HIPP

Abstract

Organophosphate neurotoxicity is attributed both to their well-known cholinergic and non-cholinergic effects. In present study we compared enzymatic and morphologic changes in neurons exposed to paraoxon. Also we studied the effect of MK-801 as an antagonism of NMDA receptor and search for neuroprotective effect of MK-801.Hippocampal cells were obtained from rat neonates and cultured in Neurobasal/B27. Paraoxon with dose of 100μM was added and the exposure time was 48 hrs. The neurons were treat with MK-801 (1 μM) 15 min prior to paraoxon. Invert, electron microscopy and neurocytochemistery staining of Map-2 were used to study cell morphology. The MTS staining was used to measure viability.The results indicate that paraoxon reduced the viability and also reduced the neurite of cells and induced apparent blebs on the surface neurons, treatment of MK-801 15 min prior to paraoxon also indeuced more reduction in viability. The area of cells reduced after exposure to paraoxon and MK-801. Also there were not repair in blebs and cell neuritis after treatment with MK-801. In conclusion MK-801 did not represent neuro protection against paraoxon (100 μM) for 48 hrs exposure.

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APA: Copy

BAHRAMI, FARIDEH, & YOUSEFPOUR, MITRA. (2009). THE EFFECT OF DIZOCILPINE (MK-801) IN NEUROTOXICITY INDUCED BY PARAOXON IN HIPPOCAMPAL CELL CULTHURE OF RAT. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903842/en

Vancouver: Copy

BAHRAMI FARIDEH, YOUSEFPOUR MITRA. THE EFFECT OF DIZOCILPINE (MK-801) IN NEUROTOXICITY INDUCED BY PARAOXON IN HIPPOCAMPAL CELL CULTHURE OF RAT. 2009. Available from: https://sid.ir/paper/903842/en

IEEE: Copy

FARIDEH BAHRAMI, and MITRA YOUSEFPOUR, “THE EFFECT OF DIZOCILPINE (MK-801) IN NEUROTOXICITY INDUCED BY PARAOXON IN HIPPOCAMPAL CELL CULTHURE OF RAT,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903842/en

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