THE INTERACTION BETWEEN ASCORBIC ACID WITH ANALGESIC EFFECT OF MORPHINE AND TRAMADOL IN MICE

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ZERAATI F.; ARAGHCHIAN M.; FARJOU MOHAMMAD HADI

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

THE INTERACTION BETWEEN ASCORBIC ACID WITH ANALGESIC EFFECT OF MORPHINE AND TRAMADOL IN MICE

Author(s)

ZERAATI F. | ARAGHCHIAN M. | FARJOU MOHAMMAD HADI

Keywords

ASCORBIC ACID

TRAMADOL

MORPHINE

ANALGESIC

Abstract

Introduction and objective: tramadol is an analgesic for severe pain which has a different pharmacological profile to that of classical opioids. Morphine is the one of the most effective drugs for treatment of acute pain. However unwanted side effects may limit their clinical use. It was found that an Intraperitoneal injection of ascorbic acid suppressed pain response induced by formalin and acetic acid, in mice. Combining analgesics of proven efficacy is a strategy that is intended to achieve improving efficacy without increasing adverse effects. In the present investigation we have evaluated the interaction between ascorbic acid with tramadol and morphine.Material & Methods: Analgesic activity was assessed by the acetic acid writhing test in mice. The effective dose that produced 20%, 50% and 65% antinociception (ED20, ED50 and ED65) wascalculated from the dose-response curve of each drug alone and coadministration of ascorbic acid with tramadol or morphine in combination of fixed ratio based on fractions of their respective ED values. By isobolographic analysis experimental EDs were compared to that theoretical EDs. The interaction index was calculated as experimental EDs/theoretical EDs.Results: Isobologram demonstrated additive effect at the ED50 and ED65 for Coadministration of ascorbic acid with tramadol and also for ascorbic acid with morphine. However at ED20 combination of ascorbic acid with tramadol (P<0.009) and ascorbic acid with morphine (P<0.008) showed synergy.Conclusion: The results of this study demonstrate interactions between ascorbic acid with tramadol and morphine. Coadministration of ascorbic acid with tramadol or morphine results in decreased adverse effects without loss of efficacy.

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APA: Copy

ZERAATI, F., ARAGHCHIAN, M., & FARJOU, MOHAMMAD HADI. (2009). THE INTERACTION BETWEEN ASCORBIC ACID WITH ANALGESIC EFFECT OF MORPHINE AND TRAMADOL IN MICE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904096/en

Vancouver: Copy

ZERAATI F., ARAGHCHIAN M., FARJOU MOHAMMAD HADI. THE INTERACTION BETWEEN ASCORBIC ACID WITH ANALGESIC EFFECT OF MORPHINE AND TRAMADOL IN MICE. 2009. Available from: https://sid.ir/paper/904096/en

IEEE: Copy

F. ZERAATI, M. ARAGHCHIAN, and MOHAMMAD HADI FARJOU, “THE INTERACTION BETWEEN ASCORBIC ACID WITH ANALGESIC EFFECT OF MORPHINE AND TRAMADOL IN MICE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/904096/en

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